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  • Differential Binding and Structural Properties of the WWC Protein Family

    Creator:
    Rodriguez, Diego Javier
    Abstract:
    The WWC family consists of three proteins‐ KIBRA/WWC1, WWC2, and WWC3. The three proteins share a similar primary structure and interact with a common set of proteins. Each paralog contains two WW domains which recognize proline‐rich sequences of the type PPxY (P is proline, Y is tyrosine, x is any...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Afua Nyarko, Mentor, representing Department of Biochemistry and Biophysics Elisar Barbar, Committee

  • Determining cytokine induced vascular maturity throughimmunohistochemical double-staining

    Creator:
    Hosack, Luke William
    Abstract:
    As a major natural component of the extracellular matrix (ECM), hyaluronic acid (HA) is an excellent choice for biomimetic, biocompatible therapeutic materials. Furthermore, thiol-modified forms of HA are capable of forming macroporous hydrogels that allow for both controlled cytokine release and extensive vessel in-growth. It has previously been shown that...
    Resource Type:
    Masters Thesis

  • Strength in Numbers: How Multivalent WW-PPXY Interactions Regulate Cell Signaling

    Creator:
    Vogel, Amber J.
    Abstract:
    Cell signaling is often mediated by protein-protein interactions, which must be specific, tunable, and transient to allow agile responsiveness to cellular messages. Due to their unique properties, multivalent, intrinsically disordered proteins make ideal candidates to accomplish these vital tasks. A single protein with multiple binding sites may bind numerous partners,...
    Resource Type:
    Dissertation
    Full Text:
    committee members: Dr. Elisar Barbar, Dr. Richard Cooley, Dr. Siva Kolluri, Dr. Glencora Borradaile, and

  • Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

    Creator:
    Otto, Shauna C.
    Abstract:
    Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
    Resource Type:
    Dissertation
    Full Text:
    roadblocks. I also thank my graduate committee, Dr. Elisar Barbar, Dr. Patrick Reardon, Dr. Joe Baio, and Dr

  • Viral Targeting of Host Hubs: Interactions between the Rabies Virus and LC8

    Creator:
    Jespersen, Nathan E.
    Abstract:
    As obligate intracellular parasites, viruses rely on host machinery for their own reproduction. Viruses are therefore required to interact with a wide variety of host proteins, despite limitations in viral genome size. The most parsimonious method of success is to hijack central and essential proteins, known as hub proteins. LC8...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: ______________________________________________________ Elisar J. Barbar As

  • Single-molecule in vitro Characterization of Otoferlin

    Creator:
    Hams, Nicole J.
    Abstract:
    Congenital hearing loss is a common disorder and over 60 mutations in the sensory hair cell protein, otoferlin, have been linked to pre-lingual deafness. Although otoferlin is essential for hearing, the large size and low solubility of the protein have limited approaches to study its function on a molecular-level. To...
    Resource Type:
    Dissertation
    Full Text:
    members, Dr. Elisar Barbar, Dr. Kate Schilke, Dr. Victor Hsu and Dr. Weihong Qiu, as well as Dr. Ryan

  • Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

    Creator:
    Narayanappa, Murugesh
    Abstract:
    Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after birth or acquired with age. Congenital hearing loss affects 32 million children in the world. The economic impact of hearing loss is estimated to cost...
    Resource Type:
    Dissertation
    Full Text:
    Qiu, Ryan Mehl, Elisar Barbara, Pankaj Jaiswal. I am extremely grateful to everyone for helping me

  • Biophysical analyses of peroxiredoxins and a partner reductase

    Creator:
    Hall, Andrea Renée
    Abstract:
    Peroxiredoxins (Prxs) are dominant peroxide-reducing enzymes with two important roles: they protect all organisms from oxidative damage induced by peroxides, and in eukaryotes, they participate in hydrogen peroxide signaling pathways. This dissertation presents studies aimed at the biophysical characterization of select Prxs and a Prx reductase to elucidate their structure-function...
    Resource Type:
    Dissertation
    Full Text:
    personally and scientifically, thank you. I thank my graduate committee members, Elisar Barbar, Janine

  • Modeling protein structure at atomic resolution

    Creator:
    Berkholz, Donald S.
    Abstract:
    This thesis includes three studies involving different aspects of modeling protein structure. The first study illustrates the levels of insight available from atomic-resolution protein structures. The second study derives general trends of protein geometry from atomic-resolution structures and shows their implications for modeling. The third study creates a model of...
    Resource Type:
    Dissertation
    Full Text:
    inflict my inexperienced mentoring upon them. I thank my graduate committee: Joe Beckman, Elisar Barbar

  • Macromolecular halogen bonds

    Creator:
    Voth, Andrea Regier
    Abstract:
    The halogen bond is a non-covalent, stabilizing interaction analogous to a hydrogen bond in which an anisotropically polarized halogen atom interacts electrostatically with a Lewis base. Until very recently, the ability of halogens to form these stabilizing interactions in biological macromolecules was all but unknown, but examples of halogen bonding...
    Resource Type:
    Dissertation
    Full Text:
    ever-present interest in my research and to Drs. Elisar Barbar and Mike Schimerlik for advice on