Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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Workshop
Paul D. Adams, Kathleen Aertgeerts, Cary Bauer, Jeffrey A. Bell, Helen M.
Berman, TalapadyN
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
,2 Cary Bauer,3 Jeffrey A. Bell,4 Helen M. Berman,5,6 TalapadyN. Bhat,7
Jeff M. Blaney,8 Evan
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Barley (Hordeum vulgare L.) possesses a large and highly repetitive genome of 5.1 Gb that has hindered the development of a complete sequence. In 2012, the International Barley Sequencing Consortium released a resource integrating whole-genome shotgun sequences with a physical and genetic framework. However, because only 6278 bacterial artificial chromosome...
The catalyst support effect on NiMoS of bio-hydrogenated diesel production was investigated via density functional theory. The activity, stability and selectivity of catalyst on three widely used catalyst supports (Al2O3, TiO2 and SiO2) were studied and compared.
Catalyst-support interaction and Brønsted acidity strength of different catalyst supports were characterized, which...
Knowledge of the mean recharge elevation (MRE) of water resources is
important for informing conservation and protection practices where water security is threatened by population growth, urban expansion, and land and climate changes. In this study a Bayesian approach was developed and applied to determine the MRE of 682 surface...
The two most economically important plant pathogens in the Pseudoperonospora (Peronosporaceae) genus are P. cubensis, causal agent of cucurbit downy mildew, and P. humuli, causal agent of hop downy mildew. These organisms have been shown to be very closely related phylogenetically and morphologically. In 2005, researchers in Korea proposed that...
Transformation is a major bottleneck for genetic engineering and gene editing in forest tree species. This includes most genotypes of Populus and Eucalyptus, which are some of the world’s most widely-cultivated genera of plantation forest trees. To provide new tools for transformation, I tested the transcription factor-protein chimera consisting of...