Cursorial ground birds are paragons of bipedal running that span a
500-fold mass range from quail to ostrich. Here we investigate the
task-level control priorities of cursorial birds by analysing how they
negotiate single-step obstacles that create a conflict between body
stability (attenuating deviations in body motion) and consistent leg...
To achieve robust and stable legged locomotion in uneven terrain, animals must effectively coordinate limb swing and
stance phases, which involve distinct yet coupled dynamics. Recent theoretical studies have highlighted the critical
influence of swing-leg trajectory on stability, disturbance rejection, leg loading and economy of walking and running. Yet,
simulations...
Full Text:
Rejection
Yvonne Blum1, Hamid R. Vejdani2, AleksandraV. Birn-Jeffery1,3, Christian M. Hubicki2,
Jonathan W
To achieve robust and stable legged locomotion in uneven terrain, animals must effectively coordinate limb swing and
stance phases, which involve distinct yet coupled dynamics. Recent theoretical studies have highlighted the critical
influence of swing-leg trajectory on stability, disturbance rejection, leg loading and economy of walking and running. Yet,
simulations...
To achieve robust and stable legged locomotion in uneven terrain, animals must effectively coordinate limb swing and stance phases, which involve distinct yet coupled dynamics. Recent theoretical studies have highlighted the critical influence of swing-leg trajectory on stability, disturbance rejection, leg loading and economy of walking and running. Yet, simulations...
Neisseria gonorrhoeae is the sexually transmitted pathogen responsible for millions of cases of gonorrhea worldwide each year. Rapidly-spreading antibiotic resistance is diminishing the ability to effectively treat a disease with significant consequences to female and male reproductive health, as well as to neonatal well-being. A protective vaccine has the potential...
Vibrio cholerae, a Gram-negative bacterium, is the etiological agent of cholera. V.
cholerae shuttles between the human host and the aquatic reservoir, where it associates
with marine organisms such as copepods and vertebrate fish. The bacteria use the Type II
Secretion System (T2SS) to release proteins that facilitate V. cholerae...
The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
Many Gram-negative bacteria use the type II secretion (T2S) pathway to deliver proteins that contribute to disease in humans, animals, and plants. Vibrio cholerae, the causative agent of the life-threatening diarrheal disease cholera, utilizes the T2S system for translocation of at least 19 proteins, including the large hexameric protein cholera...
A promising new drug target for the development of novel broad-spectrum antibiotics is the highly conserved small GTPase Obg (YhbZ, CgtA), a protein essential for the survival of all bacteria including Neisseria gonorrhoeae (GC). GC is the agent of gonorrhea, a prevalent sexually transmitted disease resulting in serious consequences on...
Radiation exposure to the brain can occur from a variety of events, including space missions, nuclear accidents, and clinical treatments. The effects of high dose radiation are well studied, but those of lower dosage are more elusive. Decline of memory and cognition is observed in patients exposed to low dose...