Colorectal cancer (CRC), the third leading cause of cancer death in the USA, depends on early detection for patient survival. Early detection is improved with the identification of high risk individuals. Risk of CRC development is a complex interaction between an individual’s genetics and environmental exposures. Polycyclic Aromatic Hydrocarbons (PAHs)...
DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic chemical compounds found in the
environment, largely as a result of partial combustion of organic compounds. PAHs are
present in the atmosphere in populated cities worldwide. Because of the health risks they
create, PAHs are a global health concern. PAHs are introduced into the...
Genomic integrity is crucial for the viability and function of a cell. One key pathway that acts to
maintain genomic integrity is DNA mismatch repair (MMR). MMR acts to correct base pair
mismatches hat have escaped proofreading during DNA replication. The process of MMR is
dependent on the protein heterodimer...
Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
Cancer economic impact is enormous and depending on the stage in which a colon cancer
is detected, five-year survival rates for colon cancer may be as high as 74%, or as low as
6% (American Cancer Society, 2012). Thus early prevention of colon cancer is crucial to
maximize the chances...
The DNA mismatch repair (MMR) pathway maintains genomic stability and
reduces cancer risk (colorectal and other internal cancers) by correcting polymerase
errors and activating cell cycle checkpoints and apoptosis in response to DNA damage.
Few studies have examined the influence of commonly encountered environmental
mutagens/carcinogens on the etiology of MMR-deficient...
Mismatch repair (MMR) system performs mainly three roles to maintain
genomic stability, correct DNA biosynthetic errors, ensure the fidelity of
genetic recombination, and in mammalian cells participate in the cellular
response to some DNA damages. Deficiencies in mismatch repair increase
mutation rates and cancer risks. In eukaryotes, the MMR system...