Cell division in a heat synchronized Tetrahymena pyriformis
(GL-I) cell can be delayed if the cell is exposed to X-irradiation (300
kVp, 20 mA, HVL = 0. 9 mm Cu, 25 R/ sec) prior to a critical time
after the end of the synchronizing treatment (EST). At the critical
time,...
Successful cell division requires proper chromosome movement, including accurate congression to the metaphase plate and proper segregation to spindle poles. Errors that occur in either event can cause chromosome aneuploidy in daughter cells, which may lead to cell death, genetic diseases and cancers (Matson and Stukenberg,2012, Compton, 2000). The force...
The effect of 2-aminoethyl-2-thiopseudourea[superscript .]Br[superscript .]HBr (AET),
2-mercaptoethylamine[superscript .]HC1 (MEA) and trisodium calcium chelate of
diethylenetriaminepentaacetic acid (CaNa₃DTPA) on the radiosensitivity
of rat fetus was investigated. A total of 1256 fetuses were
critically examined.
Exposure of rats to 200 r whole-body X-irradiation at 9.5 days
of gestation resulted in a...
Cytokinesis separates replicated chromosomes and cytoplasm into two daughter cells. In animal cells, this is achieved by the formation of a cleavage furrow that bisects the mitotic (or meiotic) spindle. It is known that the mitotic apparatus defines the cell cleavage plane. However, it is not clear how the mitotic...
Accurate chromosome segregation and cell cleavage are critical to maintaining genomic integrity. Both events involve the spindle apparatus, but the exact mechanics is as puzzling as the contradicting models proposed in the last two centuries. In this dissertation, current prevailing models of chromosome segregation and cell cleavage are tested using...
This thesis reports on computational research in two different areas. I first discuss the Min-protein system found within Escherichia coli. Following this I discuss an extended investigation into improving free energy functionals that are used within Classical Density Functional Theory in order to model water. Chapter 2 examines the dynamics...
