Attempts were made to study the effect of parathion and DDT
on the postnatal development of mice. Parathion, DDT or corn oil
(control) was administered to gravid mice during the first, second,
and third trimesters of pregnancy. Thus, nine groups of offspring
were obtained. Four different techniques, Audiogenic Seizure,
Conditioned...
It is common to characterize adrenergic receptors by placing
them in one of two categories, alpha or beta. The receptors responsible
for adrenergically induced increase in cardiac contractile force
and glycogenolysis are usually classified as beta receptors, but such
a classification is not definitely established. Therefore, an attempt
was made...
The objective of this study was to examine the published clinical
literature on the prophylactic therapy of angina pectoris with
the organic nitrates in order to determine the relationship between
experimental design and the conclusion of efficacy reported by the
investigator. A search for articles reporting original clinical investigations
on...
The inhibition of mixed-function oxidase (MFO) activity by ethanol or acetaldehyde was examined in vivo by monitoring changes in salivary half-life of antipyrine or aminopyrine in adult male Sprague-Dawley rats. Ethanol (1-6 g/kg, po) or acetaldehyde (4-8 mmol/kg, ip) was administered 20 minutes prior to antipyrine (100 mg/kg, ip) or...