WLBU2 is an engineered cationic amphiphilic peptide that targets Gram-positive and Gram-negative bacteria, and envelopes endotoxin while avoiding other cell types. The exact mechanism of how WLBU2 targets, binds, and disrupts bacterial cell membranes is still not completely known. Thus, the overall goal of this investigation is to determine the...
Cell membranes act as barriers against unwanted movement of ions and biomolecules and are complex surfaces littered with protein channels, ion channels, cholesterol, and a myriad of different proteins. While this surface is extremely well studied, there is still much we do not know. The work in this dissertation demonstrates...
Thirty-six female guinea pigs were placed on a scorbutogenic
diet for 14 days and then divided into groups of four. Three groups
received adrenocorticotropic hormone (ACTH) with each group given
10, 20, or 40 units. Three groups each received 50 mg of ascorbic
acid and three groups received 50 mg...
The boreal forest of North America is especially liable to destruction by fires. It is a region in which forest fires have been extremely common and wide spreading. Lightning is certainly one of the causes of fires but man, both aboriginal and white, has been an even more prolific source....