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  • Chandler Loop Model for the Development of Dynamic Hemocompatibility Assays

    Creator:
    Hasbrook, AnneMarie V.
    Abstract:
    A common issue with extracorporeal medical devices is blood clotting due to bio-incompatibility. Systemic anticoagulants are often prescribed to mitigate the coagulation issues. However, such drugs can lead to further complications, for example hemorrhaging. One solution to improve the hemocompatibility of blood-contacting medical devices are biomaterials, such as slippery liquid...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Adam Z. Higgins, Committee Member, representing Bioengineering

  • Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function

    Creator:
    Thierheimer, Marisa
    Abstract:
    Platelets undergo morphological changes essential to hemostasis upon activation at sites of vascular injury. The Rho GTPases Rac1, Cdc42, and RhoA drive these changes. Rho guanine nucleotide dissociation inhibitors (RhoGDIs) bind to the Rho GTPases to block the GDP from dissociating from the Rho GTPases, as well as anchoring the...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Adam Higgins, Committee Member, representing the school of Chemical, Biological, and

  • Characterization of Oxide Growth of Aluminum Alloy 6061 for Nuclear Research and Test Reactors

    Creator:
    Wei, Youran
    Abstract:
    Oxide growth is a common phenomenon on aluminum alloy cladding surfaces in nuclear research and test reactors. Without better understanding of oxide growth, excessive oxide build up on the cladding surface reduces heat transfer capability from fuel to coolant and causes safety concerns due to the potential cladding rupture or...
    Resource Type:
    Masters Thesis
    Full Text:
    Fast, David Garfinkel, Fei Teng, Benjamin Adam and Lucas teeter in reviewing the thesis and providing

  • Experimental study of subcooled water spray cooling using flow symmetric micro-structured surfaces

    Creator:
    Tulchinsky, Alex M.
    Abstract:
    Spray impingement cooling has been shown to be a leading candidate for future high heat flux cooling applications. In general, spray cooling curves consist of three heat flux regimes; single-phase, two-phase and critical heat flux (CHF). CHF is considered the design limit for almost all two-phase cooling applications, as a...
    Resource Type:
    Masters Thesis
    Full Text:
    . Sourabh Apte, and Dr. Adam Higgins, in particular Dr. Deborah Pence and Dr. James Liburdy for their

  • Machine learning approach to improve drug discovery in natural product extracts

    Creator:
    Heussner, Robert T.
    Abstract:
    Current natural product (NP) research is limited by its reliance on bioassay-guided fractionation to identify bioactive compounds in mixtures. Computational approaches may improve NP research by correlating mass spectra (MS) and nuclear magnetic resonance spectra (NMR) of bioactive mixtures to their bioactivity patterns. In this study, I use artificial neural...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Adam Higgins, Committee Member, representing Chemical, Biological, and Environmental

  • Extracorporeal Treatment of Hyperuricemia via Enzymatic Functionalized Microchannel Processing Platform (iCore): Experiment and Modeling

    Creator:
    Pantakitcharoenkul, Jaturavit
    Abstract:
    Hyperuricemia is the condition of excessive presence of plasma uric acid ≥ 6 mg/dl. Conventional clinical/hospital urate-lowering treatment includes the administration of non-steroid anti-inflammatory drugs or xanthine oxidase inhibitors. Numerous drawbacks can be observed from these conventional treatments. In patients with refractory gout symptoms and tumor lysis syndrome, recombinant uricase...
    Resource Type:
    Dissertation
    Full Text:
    much from both of you. I would like to show my appreciation to Dr. Adam Higgins for allowing me to

  • Hibernation Strategies to Improve Organ Preservation and Storage

    Creator:
    Engler, Maja T.
    Abstract:
    Looking to the natural world for insight into medical innovations is currently understudied and possibly underappreciated in the field of medicine. Natural environmental adaptations seen in wild animals can provide both inspiration and scientific realization for the future of human medicine. As humanity faces a global organ shortage crisis, research...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Adam Z. Higgins, Committee Member, representing Chemical, Biological, and Environmental

  • Ink and Substrate Compatibility for Electrochemical Sensing in Paper-based Devices

    Creator:
    Reid, Caitlin A.
    Abstract:
    Electrochemical sensing provides a quantitative alternative to colorimetric reactions within paper-based devices. The paper-based devices were fabricated by screen printing the conductive and reference inks onto porous substrates that were evaluated using cyclic voltammetry. Devices were evaluated based on the magnitude of the average anodic peak height, which correlates with...
    Resource Type:
    Honors College Thesis
    Full Text:
    Engineering _____________________________________________________________________ Adam Higgins

  • Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

    Creator:
    Laschober, Nicole B.
    Abstract:
    Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
    Resource Type:
    Honors College Thesis
    Full Text:
    University _____________________________________________________________________ Adam Higgins

  • Geometric Chatter Stability Index for Milling and Modeling of Chip Pulling Effect

    Creator:
    Maulimov, Mukhtar
    Abstract:
    Prediction and mitigation of chatter vibrations in machining operations and optimizing overall machining mechanics are crucial for achieving greater productivity and manufacturing efficiency. This thesis first explores effect of directional relationships on chatter stability in milling process. Based on the directional relationships, a geometry-based chatter stability index (CSI) is proposed...
    Resource Type:
    Masters Thesis
    Full Text:
    would like to thank Josiah Adam Breen for his assistance with the experimental setup that is used in