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  • Lipids of the Stratum Corneum as Predictive Biomarkers for the Development of Atopic Dermatitis in a Pediatric Population

    Creator:
    Sato, William
    Abstract:
    Atopic Dermatitis (AD) is a widespread skin disorder, affecting some 20% of the world’s population. Though the precise molecular underpinnings are still being understood, changes in lipid composition within the epidermal stratum corneum (SC) layer have been shown to be closely linked with AD. Previous studies have identified several specific...
    Resource Type:
    Honors College Thesis
    Full Text:
    approved: ______________________________________________________ Arup Indra Abstract Body: Atopic

  • Directing ecological succession : the role of competition in restoring semi-arid grasslands dominated by invasive plants

    Creator:
    Mangla, Seema
    Abstract:
    Successful ecosystem restoration requires an understanding of the ecological processes directing succession. One of the challenges in the semi-arid grasslands of western United States is replacement of native species by invasive annual grasses. Solutions to this problem require identifying and manipulating ecological processes that direct succession to favor desired vegetation....
    Resource Type:
    Dissertation

  • Characterization of Selective Knockout of Thioredoxin Reductase-1 (TR1) in Mouse Melanocytes In Vivo

    Creator:
    Wyant, Mark B.
    Abstract:
    Vitiligo is a disease characterized by depigmented patches of skin. The disease is known to involve the loss of melanocytes in the basal layer of the skin in affected areas, but the underlying mechanisms are unknown. Recent evidence suggests oxidative stress and disruptions to antioxidant pathways contribute to an autoimmune...
    Resource Type:
    Undergraduate Thesis
    Full Text:
    : __________________________________________ ___________ Dr. Arup K. Indra, Pharmaceutical Sciences Date

  • Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

    Creator:
    Kim, Jeonghwan
    Abstract:
    Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
    Resource Type:
    Dissertation
    Full Text:
    like to thank my thesis committee, Prof. Adam Alani, Prof. Conroy Sun, Prof. Arup Indra, and Prof

  • Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

    Creator:
    Doddapaneni, Bhuvana S.
    Abstract:
    Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
    Resource Type:
    Dissertation
    Full Text:
    my committee members Dr Oleh Taratula, Dr Mark Christensen, Dr Arup Indra and Dr Julie Greenwood

  • Dissecting the cytoskeletal interaction during cytokinesis and the role of myosin II motors on homologous chromosomes

    Creator:
    Tseng, Kuo-Fu
    Abstract:
    Prior to cell cleavage, cytokinetic proteins are recruited into the nascent actomyosin contractile ring. Interactions between spindle microtubules and the cell cortex play a critical role in this recruitment. However, direct evidence for physical interaction between microtubules and the cortex has been lacking. Here we reveal the physical connection between...
    Resource Type:
    Dissertation
    Full Text:
    my committee members, John Flower, Jeffery greenwood, Dan Rockey, Arup Indra, for their expertise

  • Biosynthetic engineering of new pactamycins

    Creator:
    Lu, Wanli
    Abstract:
    Among the myriad of naturally occurring bioactive compounds are the aminocyclopentitol-containing natural products that represent a family of sugar-derived microbial secondary metabolites, such as the antibiotics pactamycin, allosamidin, and trehazolin. Pactamycin, a structurally unique aminocyclitol antibiotic isolated from Streptomyces pactum, consists of a 5-membered ring aminocyclitol (cyclopentitol) unit, two aromatic...
    Resource Type:
    Dissertation
    Full Text:
    . Mark Zabriskie, Dr. Arup Indra, Dr. Xihou Yin, and Dr. Kerry McPhail for their valuable time and

  • Functional analysis of the biosynthetic gene cluster of the antitumor agent cetoniacytone A

    Creator:
    Wu, Xiumei
    Abstract:
    A gene cluster responsible for the biosynthesis of the antitumor agent cetoniacytone A was identified in Actinomyces sp. strain Lu 9419, an endosymbiotic bacteria isolated from the intestines of the rose chafer beetle. The nucleotide sequence analysis of the 26 Kb DNA region revealed the presence of 17 complete ORFs,...
    Resource Type:
    Dissertation
    Full Text:
    Yin, and Dr. Arup Indra, for their expertise, time, and encouragement in directing my thesis

  • Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts

    Creator:
    Kwon, Sun Hyung
    Abstract:
    The mechanisms by which the activities of phospholipase C-β (PLC-β) enzymes are negatively regulated have not been well defined. We used cardiac-derived ratmyoblast H9c2 cells to investigate possible modes of regulation of PLC-β3 enzymes,the only endogenous β isoform abundantly found in these cells. The PLC-β3population in these cells was detected...
    Resource Type:
    Masters Thesis
    Full Text:
    . Jane Ishmael, Dr. Arup Indra and Dr. Lawrence Ryan for serving on my committee and for their support

  • Nanomedicine Drug Delivery for the Treatment of Lymphatically Metastasizing Cancers

    Creator:
    Cote, Brianna M.
    Abstract:
    Nearly 80% of solid tumors, such as melanoma, metastasize via the lymphatic system. The most common form of melanoma is BRAF-mutant melanoma, and additional mutations, such as a PTEN mutation in the PI3K pathway, is required for metastases to occur. Standard therapy includes treatment with small molecules dabrafenib (DAB) and...
    Resource Type:
    Dissertation
    Full Text:
    mentorship. Thank you to Dr. Arup Indra for guidance with experimental design and data analysis. I also