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  • Harnessing the Potential of Gut Microbiome in the Context of Type 2 Diabetes

    Creator:
    Gurung, Manoj
    Abstract:
    Gut microbiota plays an essential role in health and diseases, a fact already established. With the explosive increase in obesity and its main complication, Type 2 Diabetes Mellitus (T2D), there is an immediate need for novel methods of diagnosis, prevention and treatment of these conditions. In the last one and...
    Resource Type:
    Dissertation
    Full Text:
    . Chrissa Kioussi, for their support, input and guidance. I am grateful to Dr. Susan Tilton for being on

  • Regulation of Skeletal Muscle Insulin Action and Fatty Acid Trafficking with Obesity and Exercise

    Creator:
    Stierwalt, Harrison D.
    Abstract:
    Altered skeletal muscle fat metabolism is linked to changes in skeletal muscle insulin sensitivity. Whereby the accumulation of bioactive signaling lipids (i.e., diacylglycerols and ceramides) within skeletal muscle are negatively associated with insulin sensitivity and the exercise-induced changes to fatty acid trafficking are related to improved skeletal muscle insulin action....
    Resource Type:
    Dissertation
    Full Text:
    , Chrissa Kioussi, and Urszula Iwaniec for their support, enthusiasm, and for challenging me during my

  • Functional analysis of novel β-catenin mutants

    Creator:
    Al-Fageeh, Mohamed B.
    Abstract:
    β-catenin is a multi functional protein that is involved in cell-cell adhesion and cell signaling. In non-stimulated cells, β-catenin is tightly down-regulated by GSK-3β-dependent phosphorylation at Ser and Thr residues, followed by rapid ubiquitination and proteasomal degradation. It is well established that mutations within the regulatory GSK-3β region lead to...
    Resource Type:
    Masters Thesis
    Full Text:
    would like to thank Dr. Andrew Buermeyer, Dr.Chrissa Kioussi and Dr. Jeffrey Widrick for being on my

  • Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

    Creator:
    Paraiso, Ines L.
    Abstract:
    Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
    Resource Type:
    Dissertation
    Full Text:
    for giving me the latitude to explore the most random hunches. I thank Chrissa Kioussi for her

  • Vitamin E Protects Developmental Gene Expression and Metabolic Networks in Zebrafish Embryos

    Creator:
    Head, Brian A.
    Abstract:
    Vitamin E (VitE) is necessary for vertebrate embryonic development. VitE prevents lipid peroxidation (LPO), which requires detoxification by cellular antioxidant systems subsequently involving reducing power derived from energy metabolism. Thus, VitE protects metabolic networks in the developing embryo and the integrated gene expression networks compensating for and impaired by LPO-induced...
    Resource Type:
    Dissertation
    Full Text:
    for showing us all how not to sacrifice authenticity in the pursuit of our goals. To Dr. Chrissa

  • Bcl11b is at the Nexus of Wnt and MAP Kinase Signaling Pathways in Two Stages of Thymocyte Development

    Creator:
    Selman, Wisam H.
    Abstract:
    Leukemogenesis, uncontrolled proliferation of dysfunctional, transformed immature lymphocytes, appears, especially in children, to be associated with abrogation of normal lymphopoiesis, and thymopoiesis in the case of T cell leukemias. Sequence specific transcription factors (SSTFs) are nuclear control switches that respond to cellular signals to alter cell state and cell fate...
    Resource Type:
    Dissertation
    Full Text:
    him teaching me a lot about BCL11B. I would also to thank Dr. Chrissa Kioussi for her support and

  • Biosynthesis and Rational Design of Novel Pactamycin Analogs

    Creator:
    Abugrain, Mostafa E.
    Abstract:
    Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
    Resource Type:
    Dissertation
    Full Text:
    . Chrissa Kioussi, and Dr. Kerry MacPhail for their time, guidance, suggestions, and valuable insights

  • Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

    Creator:
    Axton, Elizabeth R.
    Abstract:
    Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
    Resource Type:
    Dissertation
    Full Text:
    feedback. I would like to thank my committee members Robert Tanguay, Susan Tilton, Jane Ishmael, Chrissa

  • Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

    Creator:
    Huang, Lin
    Abstract:
    Oxidative stress is defined as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
    Resource Type:
    Dissertation
    Full Text:
    University. I would like to thank all my committee members, Dr Chrissa Kioussi, Dr Kerry McPhail, Dr Chong

  • The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

    Creator:
    Kyrylkova, Kateryna
    Abstract:
    BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...
    Resource Type:
    Dissertation
    Full Text:
    . Chrissa Kioussi, who supervised my first steps in developmental biology, and provided an example of a