Index Catalog // ScholarsArchive@OSU

Brassicas, microbes, and metabolites : a multi-omic investigation of cruciferous vegetable phytochemical metabolism

Creator:: Bouranis, John A.
Abstract:: Phytochemicals from cruciferous vegetables, such as broccoli, contain a multitude of bioactive compounds that prevent and suppress cancer and promote optimal health. Some of the health promoting effects of cruciferous vegetables are attributed to a class of compounds known as isothiocyanates (ITCs), a potent nuclear factor erythroid 2–related factor 2...
Resource Type:: Dissertation
Full Text:: Microbiome John A. Bouranis1,2, Laura M. Beaver1,2, Emily Ho1,2* 1Linus Pauling Institute, Oregon

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:: Riordan, Ruben
Abstract:: Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
Resource Type:: Dissertation
Full Text:: transfections. I would also like to thank the Biochemistry and Biophysics Department and Linus Pauling

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:: Paraiso, Ines L.
Abstract:: Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
Resource Type:: Dissertation
Full Text:: hopped pilsner beers. Journal of the Institute of Brewing 116: 445-458. 14. Karabín, M., T. Hudcová, L

Linden (Tilia cordata) associated bumble bee mortality : metabolomic analysis of nectar and bee muscle

Creator:: Lande, Claire, Rao, Sujaya, Morre, Jeffrey T., Galindo, Gracie, Kirby, Julie, Reardon, Patrick N., Bobe, Gerd, and Stevens, Jan Frederik
Abstract:: Linden (Tilia spp.), a profusely flowering temperate tree that provides bees with vital pollen and nectar, has been associated with bumble bee (Bombus spp.) mortality in Europe and North America. Bee deaths have been attributed, with inadequate evidence, to toxicity from mannose in nectar or starvation due to low nectar...
Resource Type:: Article
Full Text:: Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America, 5 Department of

Investigation of Procyanidins Used in Botanical Dietary Supplements

Creator:: Rue, Emily A.
Abstract:: Polyphenolic compounds found in foods such as fruits, vegetables, legumes, nuts and grains, are an integral part of the human diet. Within polyphenols, proanthocyanidins are referred to as condensed tannins and encompass procyanidins, propelargonidins and prodelphinidins. Among these, procyanidins are the largest group. Recent interest in these compounds is related...
Resource Type:: Dissertation
Full Text:: would like to thank the Linus Pauling Institute, Oregon State University College of Pharmacy

Influences of Replacing Cr with Mo in Fe25Co25Ni25Cr25-XMoX High Entropy Alloy Series on the Microstructure and Mechanical Properties

Creator:: Xu, Yifan
Abstract:: Fe25Co25Ni25Cr25-XMoX High Entropy Alloys were fabricated in mini arc-melter and then cast into 4mm diameter cylinders by injection casting technique and 1cm diameter cylinders by water quenching technique. Heat transfer modeling during solidification of FeCoNiCr HEA was simulated. Combining X-Ray Diffraction, Optical Microscopy, Scanning Electron Microscope, Energy Dispersive X-ray analysis,...
Resource Type:: Masters Thesis

Delivering the cell-impermeable DNA 'light-switching' Ru(II) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method

Creator:: Zhu, Ben-Zhan, Chao, Xi-Juan, Huang, Chun-Hua, and Li, Yan
Abstract:: The dipyridophenazine (dppz) based ruthenium polypyridyl complexes are known as molecular ‘light-switches’ for DNA. This property is poised to serve in diagnostic and therapeutic applications, but the poor cellular uptake restricts their use in live cells. Herein, we show that the cellular uptake, and more interestingly and surprisingly, the nuclear...
Resource Type:: Article

Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr(-/-) mice by targeting the TGFβ-Smad3 pathway

Creator:: Lytle, Kelli A., Depner, Christopher M., Wong, Carmen P., and Jump, Donald B.
Abstract:: DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr[superscript −/−] mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA at preventing WD-induced effects on...
Resource Type:: Article

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr(-/-) Mice Reversible?

Creator:: Lytle, Kelli A. and Jump, Donald B.
Abstract:: Background: Nonalcoholic fatty liver disease (NAFLD) is a major public health burden in western societies. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), is characterized by hepatosteatosis, inflammation, oxidative stress, and hepatic damage that can progress to fibrosis and cirrhosis; risk factors for hepatocellular carcinoma. Given the scope of NASH,...
Resource Type:: Article
Full Text:: Health Sciences, Oregon State University, Corvallis, Oregon, United States of America, 2 Linus Pauling

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Creator:: Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
Abstract:: Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
Resource Type:: Article

ScholarsArchive@OSU

Brassicas, microbes, and metabolites : a multi-omic investigation of cruciferous vegetable phytochemical metabolism

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Linden (Tilia cordata) associated bumble bee mortality : metabolomic analysis of nectar and bee muscle

Investigation of Procyanidins Used in Botanical Dietary Supplements

Influences of Replacing Cr with Mo in Fe25Co25Ni25Cr25-XMoX High Entropy Alloy Series on the Microstructure and Mechanical Properties

Delivering the cell-impermeable DNA 'light-switching' Ru(II) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method

Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr(-/-) mice by targeting the TGFβ-Smad3 pathway

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr(-/-) Mice Reversible?

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

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