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Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Creator:: Mahapatra, Subham
Abstract:: More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
Resource Type:: Dissertation
Full Text:: Title: Part I: Total Synthesis of Marine Macrolide Amphidinolide F and Synthetic Studies Toward

The synthesis of macrolactones from [omega]-hydroxyacyl xanthates

Creator:: Akella, Annapoorna
Resource Type:: Masters Thesis
Full Text:: placed on the ring, and are often further elaborated with one to three glycoside units. A macrolide is

Studies toward the total synthesis of sanglifehrin A

Creator:: Suttisintong, Khomson
Abstract:: Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
Resource Type:: Dissertation
Full Text:: Macrolide Analogue of SFA …………46 2.8 References………………………………………………………………….48 3. SYNTHESIS OF THE C13-C19

Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Creator:: Veerasamy, Nagarathanam
Abstract:: The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...
Resource Type:: Dissertation
Full Text:: Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A. Abstract approved

Synthetic studies on the macrolide antibiotic rutamycin B

Creator:: Wang, Shan
Resource Type:: Dissertation
Full Text:: Synthetic studies on the macrolide antibiotic rutamycin B AN

Chiral synthesis of monic acid C

Creator:: Theramongkol, Parinya
Abstract:: Bromoalkoxylation of dihydropyran with bromine and 1-borneol, followed by dehydrobromination and epoxidation, afforded trans-2-1- bornyloxy-3,4-epoxytetrahydropyran as a major product. This was treated with sodium phenylselenide to give a 1:1 mixture of (2R,3R,4R)- 2-1-bornyloxy-3-hydroxy-4-phenylselenotetrahydropyran and its (2S,3S, 4S) diastereomer. Elimination of the selenoxide, derived from oxidation of the former with hydrogen...
Resource Type:: Dissertation
Full Text:: observed low toxicity of the antibiotic in mammals. (a) (b) Hydrophobic HO OH Hydrophobic co

Advanced studies on the biosynthesis of the streptolidine moiety of streptothricin F

Creator:: Jackson, Michael D.
Resource Type:: Dissertation
Full Text:: nucleoside antibiotic produced by Streptomyces Iavendulae var. L-1689-23. The biosynthesis of the

Advanced studies of blasticidin S biosynthesis

Creator:: Zhang, Qibo
Resource Type:: Dissertation
Full Text:: S (BS, 1) is a peptidyl nucleoside antibiotic produced by Streptomyces griseochromogenes. The

Studies of the biosynthesis of Sarubicin A

Creator:: Eisenberg, Rodney L.
Abstract:: Early studies on the biosynthesis of Sarubicin A, 1, had suggested the intermediacy of the novel aromatic amino acid 6-hydroxyanthranilic acid, 17. To investigate the biosynthetic steps beyond 17, [¹³C-¹⁵N carboxamide] 6-hydroxyanthranilamide, 27a, was synthesized, and fed to fermentations of Streptomyces helicus. Incorporation of 27a into 1 provided suggestive evidence...
Resource Type:: Dissertation
Full Text:: napthoquinone antibiotic, has the 2-oxabicyclo[2.2.2]oct-5-ene structure in common with 1.6 The antibiotic G

Syntheses of labeled putative intermediates in acivicin biosynthesis

Creator:: Jiang, Nan
Resource Type:: Masters Thesis
Full Text:: of Acivicin Acivicin is an antitumor antibiotic. It also has antifungal activity. Its antibacterial

ScholarsArchive@OSU

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

The synthesis of macrolactones from [omega]-hydroxyacyl xanthates

Studies toward the total synthesis of sanglifehrin A

Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Synthetic studies on the macrolide antibiotic rutamycin B

Chiral synthesis of monic acid C

Advanced studies on the biosynthesis of the streptolidine moiety of streptothricin F

Advanced studies of blasticidin S biosynthesis

Studies of the biosynthesis of Sarubicin A

Syntheses of labeled putative intermediates in acivicin biosynthesis

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