Index Catalog // ScholarsArchive@OSU

Investigating the Interplay of Age, Zinc Status, and the Gut Microbiome on Gut Health

Creator:: Vasudevan, Anusha
Abstract:: Zinc is an important micronutrient involved in many cellular processes, including those part of immune function; however, about 15% of the US population is at risk for marginal zinc deficiency. This can lead to immune system complications including the generation of inflammatory cytokines. Aging is another factor that worsens the...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Biomedical Sciences

The Effect of Zinc Status and Age on Liver Health in Mice

Creator:: Braun, Kendra N.
Abstract:: Age-related diseases have been associated with chronic inflammation and impaired immune response, one of the hallmarks of aging. Aging individuals also have a higher susceptibility to zinc deficiency. The effects of zinc deficiency share many commonalities with the effects of aging on the immune system and zinc deficiency may be...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy R. Magnusson, Committee Member, representing Biomedical Sciences

From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

Creator:: Meeuwsen, Joseph C.
Abstract:: Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...
Resource Type:: Dissertation
Full Text:: , role modeling, and assistance. To my committee members – Drs. Emily Ho, Andy Karplus, Kathy

Investigating connections between the circadian system and aging in Drosophila melanogaster

Creator:: Long, Dani M.
Abstract:: Circadian clocks coordinate molecular, cellular, physiological, and behavioral processes with the 24-hour solar day. While clock functions are well understood in young animals, it is not clear how aging or neurodegenerative disease affects the various levels of the circadian system. A common symptom of many neurodegenerative diseases including Alzheimer’s disease...
Resource Type:: Dissertation
Full Text:: members: Dr. Barb Taylor, Dr. Patrick Chappell, Dr. Viviana Perez, and Dr. Kathy Magnusson for their

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

Creator:: Chatterjee, Paroma
Abstract:: Auditory defects and disorders are prevalent at all ages and affect 8% of the population in developed nations including newborns and children. Congenital hearing loss is the most common birth defect and it is estimated that 1 in 1000 children are affected by deafness at birth or before the onset...
Resource Type:: Dissertation
Full Text:: her support. I would also like to thank my other committee members – Prof. Kathy Magnusson, Prof

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Creator:: Campbell, Yan
Abstract:: The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
Resource Type:: Dissertation
Full Text:: Karplus and Dr. Kathy Magnusson. I thank Dr. Andy Karplus for your patience in answering my numerous

Exploring functional links between circadian clocks, neurodegeneration, and aging in Drosophila melanogaster

Creator:: Rakshit, Kuntol
Abstract:: Circadian clocks are endogenous molecular mechanisms that coordinate daily rhythms in gene expression, cellular activities, and physiological functions with external day/night cycles. Breakdown of circadian rhythms such as sleep/wake cycles is associated with the onset of several neurological diseases; however, it is not clear whether disruption of rhythms is a...
Resource Type:: Dissertation
Full Text:: . I am very thankful to my committee members, Dr. Barbara J. Taylor, Dr. Kathy R. Magnusson, Dr

Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Creator:: Hau, Andrew M.
Abstract:: Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
Resource Type:: Dissertation
Full Text:: -743): a unique mechanism of action. Mol Cancer Ther 9: 2157-2163. 8. Bai R, Pettit GR, Hamel E

Mutual mate choice in a terrestrial salamander, Plethodon shermani, with long-term sperm storage

Creator:: Eddy, Sarah L.
Abstract:: Sexual selection can influence the mating system of an organism through multiple mechanisms. These mechanisms result in variation in reproductive success among individuals, and include scramble competition, endurance rivalries, contests, mate choice and cryptic choice, and sperm competition. Understanding the mating system of a species requires the identification of which...
Resource Type:: Dissertation
Full Text:: Haig, Kathy Magnusson and Bob Mason. I am also incredibly grateful for my labmates (both here at

Pheromone mechanisms and behavioral strategies for maximizing courtship success in a terrestrial salamander, Plethodon shermani

Creator:: Vaccaro, Elyse A.
Abstract:: Darwin devised the evolutionary theory of sexual selection to account for the manifold extravagances of courtship behaviors and displays. Mating interactions represent a major evolutionary process driving the elaboration, vibrancy, and peculiarity of these courtship traits. For my dissertation research, I strived to elucidate the dynamics that constitute the complex...
Resource Type:: Dissertation
Full Text:: Olson, Kathy Magnusson, and Frank Moore for their invaluable perspective and guidance throughout the

ScholarsArchive@OSU

Investigating the Interplay of Age, Zinc Status, and the Gut Microbiome on Gut Health

The Effect of Zinc Status and Age on Liver Health in Mice

From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

Investigating connections between the circadian system and aging in Drosophila melanogaster

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Exploring functional links between circadian clocks, neurodegeneration, and aging in Drosophila melanogaster

Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Mutual mate choice in a terrestrial salamander, Plethodon shermani, with long-term sperm storage

Pheromone mechanisms and behavioral strategies for maximizing courtship success in a terrestrial salamander, Plethodon shermani

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