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  • Adjuvant vitamin E and ovarian cancer

    Creator:
    Hartman, Alysha E.
    Abstract:
    Cisplatin (CDDP) is a highly active platinum-containing chemotherapeutic agent for use against solid tumors, including ovarian. However, like most antitumor agents, CDDP use is accompanied by non-tumor tissue toxicities leading to unwanted side effects, including neuropathy. To date, the mechanism(s) for these side effects are undefined. However, the clinical features...
    Resource Type:
    Presentation

  • Gender-Dependent Mechanisms of Alpha-Tocopherol Protection from Benzo[a]pyrene Exposure in Rats

    Creator:
    Crimp, Caitlin A.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (B[a]P), are environmental pollutants linked to increased disease susceptibilities. Alpha-Tocopherol (αT) supplementation decreases B[a]P-DNA adducts in smokers, particularly women; but the mechanism is unknown. To test the hypothesis that αT protection from B[a]P exposure is gender-dependent, male and female rats received 7 daily subcutaneous...
    Resource Type:
    Honors College Thesis
    Full Text:
    : Debbie Mustacich Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (B[a]P), are