Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
Literary fairy tales facilitate a specific inquiry into heroine quests. Due to the flexibility of the fairy tale genre, a variety of heroine tales have been produced. The specific stages of a heroine quest must be described in order to understand the direction and goals of these quests. In order...
This thesis is an exploration of Catch-22 (1961) and Slaughterhouse-Five (1969), two early documents of American postmodern literature. In particular, this thesis attempts to present the critical discussions surrounding each novel as parallel to the broader theoretical discussions surrounding the concept of postmodernism. My contention is that, in both of...
In this thesis, I discuss the uses of two different forms of young adult novels for relaying messages about adolescence and femininity to adolescents from adult authors. I explore the traditional and organized quest narrative as written by Anne McCaffrey in her Harper Hall Trilogy with a young female hero....
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Kerry D. Ahearn
In this thesis, I discuss the uses of two different forms of young adult
This thesis describes the chemical investigation of marine cyanobacteria collected in Madagascar and Panama with an emphasis on the isolation and structure elucidation of medicinally relevant secondary metabolites.
A collection of the marine cyanobacterium Lyngbya majuscula from the Radames Islands, Madagascar yielded two new cyclic depsipeptides, radamamides A and B,...
Since the discovery of penicillin in 1928, the fungal kingdom has remained a fertile source for the discovery of new, biologically active, natural products. Further, as natural products continue to be discovered from fungi, a deeper understanding of the critical role of specialized metabolism in fungal ecology is afforded. The...
Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...
This thesis describes an investigation of the natural products chemistry of two fungal species of the genus Tolypocladium. Natural products are small organic molecules that are considered non-essential for cell growth and reproduction, and thus part of secondary metabolism. Chemical profiling of these secondary metabolites using a combination of high-performance...
Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
Climate change remains controversial and misunderstood, despite the consensus among climate scientists that recent climate change is anthropogenic. Many American adults do not agree with or do not understand this scientific consensus, suggesting a disconnect in science communication or a distrust in science. This disconnect may begin in formal education...