In eukaryotes, the defined loci on each chromosome, the centromeres, accomplish
the critical task of correct cell division. In some organisms, centromeres are
composed of a euchromatic central core region embedded in a stretch of
heterochromatin and the inheritance and maintenance of centromeres are controlled
by dynamic epigenetic phenomena. Although...
Trichoderma reesei is an industrial producer of enzymes that degrade lignocellulosic polysaccharides to soluble monomers, which can be fermented to biofuels. Here we show that the expression of genes for lignocellulose degradation are controlled by the orthologous T. reesei protein methyltransferase LAE1. In a lae1 deletion mutant we observed a...
Magnetic particle imaging (MPI) is a biomedical imaging technique which detects the presence of magnetic nanoparticles which have been introduced into the specimen prior to imaging. MPI has shown promise for real-time imaging with spatial resolution comparable to magnetic resonance imaging (MRI). MPI research has focused predominantly on the development...
Surface acoustic wave (SAW) sensors are versatile devices that can be configured to sense a variety of measurands such as temperature and pressure. The potential use of surface acoustic wave devices for magnetic field detection is explored in this study. Compared to current magnetic field sensors, a sensor based on...
This work demonstrates correlation of microwave signals encoded with 16-bit codes using the parametric interaction of spin waves. Signal processing correlators are devices that compare two signals, such as a reference code and a received code, where the output indicates the similarity between the signals. Correlators are used in communication...
In this work, an alternating current (ac) magnetic susceptometer is designed and implemented to track the Brownian relaxation time of magnetic nanoparticles that are suspended in a liquid medium. The detection technique based on the Brownian relaxation time of magnetic nanoparticles has found its way in a variety of biosensing...
Inkjet printing offers a cost effective, highly customizable method for rapid manufacturing of functional devices with minimal material waste. Although this method has been used for a variety of composites, little work has been done in the area of 3D printing magnetic composites. Presented here is a process for inkjet...
The Amplitude and phase of surface acoustic waves can be characterized using a laser beam and photodiode detector. This paper describes a technigue for charactarizing waves using the double photodiode method. This method is a modification of the knife-edge method, and involves focusing a laser beam to a beam spot...
The objective of this thesis is to introduce and demonstrate a novel magnetic bead detector based on inductive detection at the ferromagnetic resonance (FMR) frequency for use in bio-sensing applications. Detection ability is demonstrated through theoretical arguments, numerical computer simulations, and experimental characterization of micro-fabricated detectors.
The detector is composed...
Magnetically programmable surface acoustic wave (MP SAW) devices were designed, fabricated and characterized in this thesis using integrated giant magnetoresistive (GMR) bits with interdigital reflectors. This provides a proof of concept of a novel storage element on radio frequency identification tags. Interdigital transducers (IDTs) on a piezoelectric substrate are used...