The mechanisms by which the activities of phospholipase C-β (PLC-β) enzymes are negatively regulated have not been well defined. We used cardiac-derived ratmyoblast H9c2 cells to investigate possible modes of regulation of PLC-β3 enzymes,the only endogenous β isoform abundantly found in these cells. The PLC-β3population in these cells was detected...
Numerous tests were applied to rainbow trout
of eleven months of age to determine whether
ascorbic acid is an essential element of the diet
of these fish. Although previous work had been
done on this question, conflicts in the results,
the large reliance upon abnormal symptoms such as
lordosis and...
During extreme exercise, athletes experience increased inflammation that is similar to the acute phase response. Endurance athletes, distance runners in particular, are also more susceptible to compromised iron stores. This study evaluated inflammation, immune function and iron status in athletes completing a 50K ultramarathon. Twenty-two well-trained distance runners, 11 males...
To determine if 6 weeks prior supplementation with vitamins E and C
could alleviate exercise-induced DNA damage, prevent lipid peroxidation and
inflammation, slow the rate of vitamin E utilization and/or attenuate muscle
damage, 22 subjects (11 females: 11 males) were studied during a 50 km (32
mile) ultramarathon. Subjects were...
Oxidative stress is the major driving force behind the aging process and many age-related diseases. However, direct experimental evidence of whether antioxidants, such as ascorbate (AA) and lipoic acid (LA) can slow the progression of aging process and/or reduce risks of developing degenerative disease is largely absent. This suggests a...