Preliminary toxicity studies of BCNU in rats revealed that significant
prolongations of pentobarbital hypnosis were associated with
all doses employed. Investigations were undertaken to determine the
underlying mechanism responsible for this observed effect. Studies
on the in vitro metabolism of pentobarbital by hepatic microsomes
of BCNU-treated animals demonstrated that significant...
There has been no toxicologic proof that the long-term, low-level
exposure of man to chlorophenothane (DDT) is linked with an
increased susceptibility to toxicity or disease. Acute pretreatment
of rats with 75-100 mg/kg DDT has been demonstrated to potentiate
CCI₄-induced hepatotoxicity in that species (McLean and McLean,
1966). Since the...
Electrical stimulation of the vagus nerves produces an excitatory
contraction response in the isolated rat stomach. This contraction
response was abolished by atropine to unmask the vagal inhibitory
response (VIR) elicited during low frequency vagal stimulation.
Babring and Gershon (1967), after working on guinea-pigs and mice,
hypothesized that both serotonin...
The level of postganglionic sympathetic nerve activity is
important in determining the tone of vascular smooth muscle, and
subsequent maintenance of normal blood pressure. It is generally
agreed that receptors located on postganglionic nerve terminals
(pre-junctional alpha₂ receptors) are important in the modulation of
neurotransmitter (norepinephrine) release from these nerves....
Published July 1952. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
There is need for more knowledge of the naturally acquired
diseases of the laboratory rat. Respiratory diseases occurring in
the species were reviewed with special reference to an acute respiratory
disease affecting certain rats in the Oregon State University
closed Wistar rat colony which has also involved human infections.
The...
Corn oil (CO) and Sterculic foetida oil (SFO) fed rats were
injected with [9, 10-methylene-¹⁴C]sterculic acid. Less than 1%
of the label was expired as carbon dioxide. The majority of the
label was excreted in the urine as short-chain dicarboxylic acids with
an intact cyclopropane ring. The major metabolites for...