Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...
In this thesis we develop a theoretical framework for the identification of situations where the equal frequency (EF) or equal variance (EV) subclassification may produce lower bias and/or variance of the estimator. We conduct simulation studies to examine the EF and EV approaches under different types of model misspecification. We...
Posting advisory speed signs at sharp horizontal curve locations is a common practice in the U.S. These signs recommend drivers safe speeds to negotiate such curves. Literature indicates that adherence to advisory speeds is, in general, poor. Moreover, limited research is available that quantifies safety implications of these signs. This...
The Forest Inventory and Analysis (FIA) program conducts an annual inventory throughout the United States. In the western United States, 10% of all plots (one panel) are measured annually, and a moving average is used for estimating current condition and change of forest attributes while alternative methods are sought in...
This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
This dissertation is about the likelihood analysis of ordered categorical responses in a longitudinal/spatial study, meaning regression-like analysis when the response variable is categorical with ordered categories, and is measured repeatedly over time or space on the experimental or sampling units. Particular attention is given to the multivariate ordinal probit...
A study of nucleate boiling of water, four alcohols and
three ethanol-water mixtures was conducted in a vertical
thermosiphon reboiler. The test section consisted of a 1/2-
inch diameter electrically heated stainless-steel rod
jacketed by a 15-inch long pyrex glass tube. Two different
inside diameters of the glass tube corresponding...
The purposes of this study were to determine
relationships between burnout and selected demographic
and job-related variables and to identify burnout coping
strategies commonly used by teacher-coaches in public
secondary schools. A volunteer sample of 193 teacher-coaches
responded to a three-section questionnaire
composed of the Maslach Burnout Inventory, the Jaloweic...
Product development efforts are extremely important to a company's success in today's global competitive business environment. Yet, these highly consequential efforts are terribly nebulous to a point that past experiences are inherently underutilized. This thesis demonstrates a methodology to quantify past product development efforts in an attempt to better utilize...