We consider long planetary waves of annual period linearized about a steady, wind-driven subtropical (ST) gyre circulation. The circulation divides the gyre into an eastern zone (EZ) where only the surface layer is in steady motion and a western zone (WZ) where both the surface and the middle layer are...
Satellite observations and idealized numerical studies reveal intensification of long-period (on the order of one cycle per year) waves in the western part of ocean basins. The authors explore the idea that the intensification is associated with the spatial growth of purely time periodic, but baroclinically unstable, motions. The framework...
The purpose of this paper is to understand how long planetary waves evolve when propagating in a subtropical gyre. The steady flow of a wind-driven vertically sheared model subtropical gyre is perturbed by Ekman pumping that is localized within a region of finite lateral extent and oscillates periodically at about...
An emerging area in environmental toxicology is the role that chemicals and chemical mixtures have on the cells of the human immune system. This is an important area of research that has been most widely pursued in relation to autoimmune diseases and allergy/asthma as opposed to cancer causation. This is...
An increasing number of studies suggest an important role of host immunity as a barrier to tumor formation and progression. Complex mechanisms and multiple pathways are involved in evading innate and adaptive immune responses, with a broad spectrum of chemicals displaying the potential to adversely influence immunosurveillance. The evaluation of...
One of the important ‘hallmarks’ of cancer is angiogenesis, which is the process of formation of new blood vessels that are necessary for tumor expansion, invasion and metastasis. Under normal physiological conditions, angiogenesis is well balanced and controlled by endogenous proangiogenic factors and antiangiogenic factors. However, factors produced by cancer...
Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically,...
Environmental contributions to cancer development are widely accepted, but only a fraction of all pertinent exposures have probably been identified. Traditional toxicological approaches to the problem have largely focused on the effects of individual agents at singular endpoints. As such, they have incompletely addressed both the pro-carcinogenic contributions of environmentally...