The numerous different types of nanomaterials and paucity of reliable in vivo information on toxicity has resulted in enduring uncertainties associated with health and safety risks, thereby slowing progress in nanotherapeutic assessment and development. This dissertation explores how the embryonic zebrafish model can be applied to prioritize commonly used nanomaterial...
Glioblastoma Multiform
• Type of aggressive brain cancer
• Five year survival rate of 4.70%
• Not often detected until it’s in the later stages when
the symptoms appear
• Surgery is not an effective option due to invasion and
proliferation of glioblastoma cells outside of the tumor
mass before...
The fish early-life stage (FELS) test (Organisation for Economic Co-operation and Development [OECD] test guideline 210) is the
primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical management programs.
As part of an ongoing effort to develop efficient and cost-effective alternatives to...
Full Text:
TANGUAY,zz LISA TRUONG,zz and LEAH WEHMASzz
yUS Environmental Protection Agency, Duluth, Minnesota, USA
The fish early-life stage (FELS) test (Organisation for Economic Co-operation and Development [OECD] test guideline 210) is the
primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical management programs.
As part of an ongoing effort to develop efficient and cost-effective alternatives to...
The fish early-life stage (FELS) test (Organisation for Economic Co-operation and Development [OECD] test guideline 210) is the primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical management programs. As part of an ongoing effort to develop efficient and cost-effective alternatives to...
Glioblastoma multiforme is the most common primary brain tumor in adults ages 45-70, with over 12,120 new cases in the U.S. predicted for 2016 alone. Glioblastoma is also one of the most difficult cancers to treat because the tumor cells tend to invade into the surrounding healthy tissue, making it...
Glioblastoma multiforme is the most common primary brain tumor in adults ages 45-70, with over 12,120 new cases in the U.S. predicted for 2016 alone. Glioblastoma is also one of the most difficult cancers to treat because the tumor cells tend to invade into the surrounding healthy tissue, making it...
Glioblastoma multiforme is a devastating primary brain tumor with a median five year survival rate of less than 5%. It is a cancer that is resistant to current cancer treatments, such as surgery and chemotherapy, as well as one that is prone to recurrence after surgical removal. This highlights the...
Sensory hair cells convert mechanical motion into chemical signals. Otoferlin, a six-C2 domain transmembrane protein linked to deafness in humans, is hypothesized to play a
role in exocytosis at hair cell ribbon synapses. To date however, otoferlin has been
studied almost exclusively in mouse models, and no rescue experiments have...
Glioblastoma, which occurs in adults primarily between ages of 40 to 70 years and accounts for 15% of all brain tumors, is a devastating diagnosis with a median survival rate of less than a year. Invasiveness of glioblastoma cells significantly reduces the effectiveness of current treatments, highlighting the importance of...