The biorevolution in the 1970’s greatly stimulated investment in life-science
research. The present dissertation is aimed at evaluating the impact of US public
investment on industrial investment in life-science research. The focus is on three major
life-science fields: biology, medicine, and agriculture. A dynamic model of industrial
R&D investment is...
The performance of the meat products industry, the largest food processing sector in the U.S. in terms of shipment value, is an important issue. A key indicator of its performance is productivity growth, which results in reduction in the cost of production at given input prices. The present study employs...
The genetic engineering made possible by the discovery of recombinant DNA has played an increasingly important role in agricultural research. The present study employs a knowledge production model to assess the efficacy of, and relationship between, basic and applied research in agricultural biotechnology, allowing for both complementarity and substitutability between...
The cycloundecapeptide cyclosporin A (CsA) was first isolated from the insect-pathogenic fungus Tolypocladium inflatum for its antifungal activity and later developed as an immunosuppressant drug. However, the full biosynthetic mechanism of CsA remains unknown and has puzzled researchers for decades. In this study, the biosynthetic gene cluster is suggested to...
One of the important ‘hallmarks’ of cancer is angiogenesis, which is the process of formation of new blood vessels that are necessary for tumor expansion, invasion and metastasis. Under normal physiological conditions, angiogenesis is well balanced and controlled by endogenous proangiogenic factors and antiangiogenic factors. However, factors produced by cancer...
The focus of this thesis is to design, characterize, and apply novel computational methods and molecular systems to interrogate heterogeneous human gut microbiome-related phenomena. In Chapter 2, I design, implement, and characterize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets. I use this method to 1....
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that...
The appearance of detritus shed from mountain ranges along the northern margin of the Tibetan Plateau heralds the Cenozoic development of high topography. Current estimates of the age of the basal conglomerate in the Qaidam basin place this event in Paleocene-Eocene. Here we present new magnetostratigraphy and mammalian biostratigraphy that...
Cancer is currently the second leading cause of death in the United States and the sixth leading cause of death worldwide. Due to cancer’s variability in type, location, growth rates, and patient physiology, treatment models are based off of previous experimental and clinical work. This variability, however, can lead to...
Canine Transitional Cell Carcinoma (TCC) makes up 2% of all canine cancers and is the most common cancer of the bladder for dogs. Usually diagnosed in its later stages, TCC is difficult to treat, with low survival times. Current diagnosis involves invasive techniques, and mainstream screening tests are often ineffective....
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source software
MetaboAnalyst3.0 for statistical analysis (Xia, 2015). Distinct
features between the