Index Catalog // ScholarsArchive@OSU

Biologically Active Secondary Metabolites from Red Sea Cyanobacteria

Creator:: Alhadab, Ali A.
Abstract:: This project describes the investigation of marine cyanobacteria collected from the Red Sea with an emphasis on the identification and prioritization of biologically active fractions for future purification and molecular structure elucidation of medicinally relevant secondary metabolites. Five crude extracts of taxonomically unidentified Red Sea cyanobacteria supplied by Egyptian collaborators...
Resource Type:: Honors College Thesis
Full Text:: Mark Zabriskie ALHADA01 Typewritten Text Christopher Thornburg ACKNOWLEDGMENTS First, I

Synthesis and opioid activity of dynorphin analogues with the modifications in the message sequence

Creator:: Kulkarni, Sandhya N.
Resource Type:: Masters Thesis
Full Text:: members, Dr. Douglas Barofsky, Dr. Mark Zabriskie and Dr. Markle Douglas. I appreciate the cooperation

Effects of quinolinate and nitro-, or thio- substituted analogs of quinolinate on glutamate receptor-mediated neurotoxicity in cerebellar granule cell cultures

Creator:: Zhang, Jinying
Abstract:: Quinolinate (QUIN) is an endogenous neurotoxic product of the kynurenine pathway of tryptophan metabolism. Quinolinate is a selective agonist of the NMDA family of glutamate receptors and, as such, may play a role in the pathology of a number of major central nervous system (CNS) disorders. These include both chronic...
Resource Type:: Masters Thesis
Full Text:: possible. I owe my deepest gratitude to Dr. Mark Zabriskie and Ms. Hua Qi for their work supplying me

Characterization of the genomic islands from tetracycline-resistant Chlamydia suis

Creator:: Dugan, Jae
Abstract:: Tetracycline (Tet)-resistant strains of Chlamydia suis were isolated from swine farms in the Midwest. The isolation of the resistant strains was significant because Tet is an antibiotic used to treat infections by veterinarians and doctors. One of the tetracycline (Tet)-resistant strains, R19, was able to survive in Tet up to...
Resource Type:: Dissertation
Full Text:: , Mahfuz Sarker, Mark Zabriskie, Doug Barofsky, and Claudia Hase. Not only has Dennis Hruby and Mark

Biosynthesis studies and mutasynthesis of myxobacterial secondary metabolites

Creator:: Knight, Eva W.
Abstract:: Myxobacteria represent an interesting class of Gram-negative soil bacteria. These bacteria utilize organic materials from the environment as a food source by the action of their extracellular hydrolytic enzymes. They grow vegetatively in the presence of adequate nutrients. During starvation conditions, however, they aggregate and form multicellular structures called fruiting...
Resource Type:: Masters Thesis

Transcriptional repression mediated by a novel family of C₂H₂ zinc finger proteins

Creator:: Senawong, Thanaset
Abstract:: Two novel and highly related C₂H₂ zinc finger proteins (CTIP1/BCL11A/EVI9 and CTIP2/BCL11B/Rit1) have been implicated in COUP-TF signaling, etiology of myeloid and lymphoid malignancies, and hematopoietic cell development. However, the precise cellular function(s) and the contribution of these proteins to neoplastic processes and hematopoietic cell development remain unknown. The goal...
Resource Type:: Dissertation
Full Text:: graduate committee, Drs. Mark Zabriskie, George Pearson, Walt Ream, and Mark Harmon, for their comments

Biosynthesis and Rational Design of Novel Pactamycin Analogs

Creator:: Abugrain, Mostafa E.
Abstract:: Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
Resource Type:: Dissertation
Full Text:: work. I would like to thank my committee members Dr. Barbara Taylor, Dr. Mark Zabriskie, Dr

Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

Creator:: Sheng, Yan
Abstract:: The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically...
Resource Type:: Dissertation
Full Text:: invaluable to me. I am so thankful to my advisory committee members Dr. Mark Zabriskie, Dr. Philip

Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

Creator:: Abuelizz, Hatem A.
Abstract:: This thesis describes an investigation of the molecular basis of the substrate specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a newly discovered group of glycosyltransferase (GT)-like proteins that catalyze the transfer of a pseudosugar to an acceptor molecule via a C-N bond formation. This...
Resource Type:: Dissertation
Full Text:: work. I also thank my thesis committee members Dr. Mark Zabriskie, Dr. Kerry McPhail, Dr. Fred

Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

Creator:: Vining, Oliver B.
Abstract:: Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
Resource Type:: Dissertation
Full Text:: also wish to thank Dr. Mark Zabriskie and Dr. Taifo Mahmud for their advice and support, as well as

ScholarsArchive@OSU

Biologically Active Secondary Metabolites from Red Sea Cyanobacteria

Synthesis and opioid activity of dynorphin analogues with the modifications in the message sequence

Effects of quinolinate and nitro-, or thio- substituted analogs of quinolinate on glutamate receptor-mediated neurotoxicity in cerebellar granule cell cultures

Characterization of the genomic islands from tetracycline-resistant Chlamydia suis

Biosynthesis studies and mutasynthesis of myxobacterial secondary metabolites

Transcriptional repression mediated by a novel family of C₂H₂ zinc finger proteins

Biosynthesis and Rational Design of Novel Pactamycin Analogs

Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

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