Graduate Thesis Or Dissertation

 

Extensions of the proportional hazards loglikelihood for censored survival data Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/ws859j61k

Descriptions

Attribute NameValues
Creator
Abstract
  • The semi-parametric approach to the analysis of proportional hazards survival data is relatively new, having been initiated in 1972 by Sir David Cox, who restricted its use to hypothesis tests and confidence intervals for fixed effects in a regression setting. Practitioners have begun to diversify applications of this model, constructing residuals, modeling the baseline hazard, estimating median failure time, and analyzing experiments with random effects and repeated measures. The main purpose of this thesis is to show that working with an incompletely specified loglikelihood is more fruitful than working with Cox's original partial loglikelihood, in these applications. In Chapter 2, we show that the deviance residuals arising naturally from the partial loglikelihood have difficulties detecting outliers. We demonstrate that a smoothed, nonparametric baseline hazard partially solves this problem. In Chapter 3, we derive new deviance residuals that are useful for identifying the shape of the baseline hazard. When these new residuals are plotted in temporal order, patterns in the residuals mirror patterns in the baseline hazard. In Chapter 4, we demonstrate how to analyze survival data having a split-plot design structure. Using a BLUP estimation algorithm, we produce hypothesis tests for fixed effects, and estimation procedures for the fixed effects and random effects.
Resource Type
Date Available
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Publisher
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi (Monochrome, 8-bit Grayscale) using ScandAll PRO 1.8.1 on a Fi-6770A in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2012-09-06T21:26:02Z (GMT) No. of bitstreams: 1 DerryberryDeWayneR1999.pdf: 3428564 bytes, checksum: 8264b6800f527a9e6f08dc534684e8e6 (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2012-09-06T21:24:26Z (GMT) No. of bitstreams: 1 DerryberryDeWayneR1999.pdf: 3428564 bytes, checksum: 8264b6800f527a9e6f08dc534684e8e6 (MD5)
  • description.provenance : Made available in DSpace on 2012-09-06T21:26:02Z (GMT). No. of bitstreams: 1 DerryberryDeWayneR1999.pdf: 3428564 bytes, checksum: 8264b6800f527a9e6f08dc534684e8e6 (MD5) Previous issue date: 1998-09-22
  • description.provenance : Submitted by Kaylee Patterson (kdpscanner@gmail.com) on 2012-09-06T20:19:52Z No. of bitstreams: 1 DerryberryDeWayneR1999.pdf: 3428564 bytes, checksum: 8264b6800f527a9e6f08dc534684e8e6 (MD5)

Relationships

Parents:

This work has no parents.

In Collection:

Items