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Browsing by Author "Freitag, Michael"
Now showing items 1-20 of 28
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Eaton, Hillary L. (2011-05-05)Cyclic nitramines released into all environmental compartments through anthropogenic activities are toxic and possibly carcinogenic and mutagenic. Soils on military ranges, located throughout the world in various climati ...
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Khuu, Patricia A. (2008-07-14)The structural polymorphic nature of DNA has been long been recognized since the model of the right-handed B-DNA duplex proposed by James Watson and Francis Crick was accepted. Its malleability is thought to be critical ...
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Sinnott, Brian D. (2011-02-21)Antimicrobial peptides (AMPs) play an important role in the innate immune system. Determining the pathways by which these proteins are regulated allows for modulation of their expression for better health. Two families o ...
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Puckett, Susan E.; Reese, Kaleb A.; Mitev, Georgi M.; Mullen, Valerie; Johnson, Rudd C.; Pomraning, Kyle R.; Mellbye, Brett L.; Tilley, Lucas D.; Iversen, Patrick L.; Freitag, Michael; Geller, Bruce L. (American Society for Microbiology, 2012-12)Peptide phosphorodiamidate morpholino oligomers (PPMO) are synthetic DNA mimics that bind complementary RNA and inhibit bacterial gene expression. (RFF)₃RXB- AcpP PPMO (R, arginine; F, phenylalanine; X, 6-aminohexanoic a ...
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Hall, Justin Daniel (2010-05-14)Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediat ...
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Lal, Sangeet Kumar (2011-02-01)Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain du ...
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Pomraning, Kyle R. (2012-11-20)Mutation of repetitive DNA by repeat-induced point mutation (RIP) is a process that occurs in many filamentous fungi of the Ascomycota during the sexual cycle. Concurrently, direct DNA repeats are often deleted by homolo ...
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Shorey, Lyndsey E. (2012-05-24)Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been do ...
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Lepesant, Julie M. J.; Cosseau, Celine; Boissier, Jerome; Freitag, Michael; Portela, Julien; Climent, Deborah; Perrin, Cecile; Zerlotini, Adhemar; Grunau, Christoph (BioMed Central Ltd., 2012-02-29)Background: In the leuphotrochozoan parasitic platyhelminth Schistosoma mansoni, male individuals are homogametic (ZZ) whereas females are heterogametic (ZW). To elucidate the mechanisms that led to the emergence of sex ...
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Manning, Viola A.; Pandelova, Iovanna; Dhillon, Braham; Wilhelm, Larry J.; Goodwin, Stephen B.; Berlin, Aaron M.; Figueroa, Melania; Freitag, Michael; Hane, James K.; Henrissat, Bernard; Holman, Wade H.; Kodira, Chinnappa D.; Martin, Joel; Oliver, Richard P.; Robbertse, Barbara; Schackwitz, Wendy; Schwartz, David C.; Spatafora, Joseph W.; Turgeon, B. Gillian; Yandava, Chandri; Young, Sarah; Zhou, Shiguo; Zeng, Qiandong; Grigoriev, Igor V.; Ma, Li-Jun; Ciuffetti, Lynda M. (The Genetics Society of America, 2013-01)Pyrenophora tritici-repentis is a necrotrophic fungus causal to the disease tan spot of wheat, whose contribution to crop loss has increased significantly during the last few decades. Pathogenicity by this fungus is attr ...
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Reese, Kaleb A. (2011-09-09)Novel mucosal vaccines (LL-M2e, LL-HAe, SG-HAe) were constructed from live, non-pathogenic Lactococcus lactis or Streptococcus gordonii that express conserved regions of HA or M2 antigens from avian influenza virus (AIV) ...
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Vining, Kelly J.; Pomraning, Kyle R.; Wilhelm, Larry J.; Priest, Henry D.; Pellegrini, Matteo; Mockler, Todd C.; Freitag, Michael; Strauss, Steven H. (BioMed Central Ltd, 2012-01-17)Background: DNA cytosine methylation is an epigenetic modification that has been implicated in many biological processes. However, large-scale epigenomic studies have been applied to very few plant species, and variabili ...
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Cabrera Orozco, Yohanna (2010-09-03)Treating durable, second-growth or plantation-grown material with supplemental chemicals could improve durability while enhancing the uniformity of the products. To test this hypothesis, the effect of two candidate bioci ...
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Wilcox, Buck W. L. (2012-03-13)Genomic instability underlies diseases of unregulated cell growth that result in cancers and developmental abnormalities in humans. Similar genome destabilizing mechanisms are used to create genetic variety in crops fo ...
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Karimi-Aghcheh, Razieh; Bok, Jin Woo; Phatale, Pallavi A.; Smith, Kristina M.; Baker, Scott E.; Lichius, Alexander; Omann, Markus; Zeilinger, Susanne; Seiboth, Bernhard; Rhee, Catherine; Keller, Nancy P.; Freitag, Michael; Kubicek, Christian P. (The Genetics Society of America, 2013-02-01)The putative methyltransferase LaeA is a global regulator that affects the expression of multiple secondary metabolite gene clusters in several fungi, and it can modify heterochromatin structure in Aspergillus nidulans. ...
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Vidal-Dupiol, Jeremie; Zoccola, Didier; Tambutte, Eric; Grunau, Christoph; Cosseau, Ce´line; Cosseau, Celine; Smith, Kristina M.; Freitag, Michael; Dheilly, Nolwenn M.; Allemand, Denis; Tambutte, Sylvie (Public Library of Science, 2013-03-27)Since the preindustrial era, the average surface ocean pH has declined by 0.1 pH units and is predicted to decline by an additional 0.3 units by the year 2100. Although subtle, this decreasing pH has profound effects on ...
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Slavov, Gancho T.; DiFazio, Stephen P.; Martin, Joel; Schackwitz, Wendy; Muchero, Wellington; Rodgers-Melnick, Eli; Lipphardt, Mindie F.; Pennacchio, Christa P.; Hellsten, Uffe; Pennacchio, Len A.; Gunter, Lee E.; Ranjan, Priya; Vining, Kelly; Pomraning, Kyle R.; Wilhelm, Larry J.; Pellegrini, Matteo; Mockler, Todd C.; Freitag, Michael; Geraldes, Armando; El-Kassaby, Yousry A.; Mansfield, Shawn D.; Cronk, Quentin C. B.; Douglas, Carl J.; Strauss, Steven H.; Rokhsar, Dan; Tuskan, Gerald A. (John Wiley & Sons, Inc., 2012-11)•Plant population genomics informs evolutionary biology, breeding, conservation and bioenergy feedstock development. For example, the detection of reliable phenotype–genotype associations and molecular signatures of sele ...
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Kimbrel, Jeffrey A. (2012-03-13)Symbiosis is the close and protracted interaction between organisms. The molecular interactions that occur during symbiosis are complex with multiple barriers that must be overcome. Many Gram-negative, host-associated ba ...
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Zhu, Ruoqing (2011-09)Epigenetic mechanisms are important for control of plant development, and may play a particularly important role in trees given their long life cycles and distinctive and stable tissue types. To help understand the role ...
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Ishikawa, Francine H.; Souza, Elaine A.; Shoji, Jun-ya; Connolly, Lanelle; Freitag, Michael; Read, Nick D.; Roca, M. Gabriela (2012-02-02)It has been hypothesized that horizontal gene/chromosome transfer and parasexual recombination following hyphal fusion between different strains may contribute to the emergence of wide genetic variability in plant patho ...
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