http://hdl.handle.net/1957/31640 2013-05-26T04:27:33Z 2013-05-26T04:27:33Z Sikora, Aleksandra E. http://hdl.handle.net/1957/38706 2013-05-22T16:46:33Z 2013-02-21T00:00:00Z

Proteins Secreted via the Type II Secretion System: Smart Strategies of Vibrio cholerae to Maintain Fitness in Different Ecological Niches Sikora, Aleksandra E. No abstract available. This is the publisher’s final pdf. The published article is copyrighted by Public Library of Science and can be found at: http://www.plos.org/.

2013-02-21T00:00:00Z Taratula, Oleh Kuzmov, Andriy Shah, Milin Garbuzenko, Olga B. Minko, Tamara http://hdl.handle.net/1957/38581 2013-05-22T21:34:00Z 2013-04-28T00:00:00Z

Nanostructured Lipid Carriers as Multifunctional Nanomedicine Platform for Pulmonary Co-Delivery of Anticancer Drugs and siRNA Taratula, Oleh; Kuzmov, Andriy; Shah, Milin; Garbuzenko, Olga B.; Minko, Tamara We developed, synthesized, and tested a multifunctional nanostructured lipid nanocarrier- based system (NLCS) for efficient delivery of an anticancer drug and siRNA directly into the lungs by inhalation. The system contains: (1) nanostructured lipid carriers (NLC); (2) anticancer drug (doxorubicin or paclitaxel); (3) siRNA targeted to MRP1 mRNA as a suppressor of pump drug resistance; (4) siRNA targeted to BCL2 mRNA as a suppressor of nonpump cellular resistance and (5) a modified synthetic analog of luteinizing hormone- releasing hormone (LHRH) as a targeting moiety specific to the receptors that are overexpressed in the plasma membrane of lung cancer cells. The NLCS was tested in vitro using human lung cancer cells and in vivo utilizing mouse orthotopic model of human lung cancer. After inhalation, the proposed NLCS effectively delivered its payload into lung cancer cells leaving healthy lung tissues intact and also significantly decreasing the exposure of healthy organs when compared with intravenous injection. The NLCS showed enhanced antitumor activity when compared with intravenous treatment. The data obtained demonstrated high efficiency of proposed NLCS for tumor-targeted local delivery by inhalation of anticancer drugs and mixture of siRNAs specifically to lung cancer cells and, as a result, efficient suppression of tumor growth and prevention of adverse side effects on healthy organs.

2013-04-28T00:00:00Z Danielson, Jennifer Ramirez, Juancho Krueger, Janelle Christensen, Lindsay Harshberger, Cara A. Rice, Luke Hudgins, Gayle A. Weber, Stanley http://hdl.handle.net/1957/38266 2013-04-19T21:30:14Z 2011-12-15T00:00:00Z

The Capacity Ratio as a Measure of Solvency in Experiential Education Danielson, Jennifer; Ramirez, Juancho; Krueger, Janelle; Christensen, Lindsay; Harshberger, Cara A.; Rice, Luke; Hudgins, Gayle A.; Weber, Stanley Objective. To determine the utility of the capacity ratio to measure and compare solvency in experiential education in 6 colleges and schools of pharmacy in the Northwestern United States. Methods. The 6 colleges and schools of pharmacy combined data on student placements needed, site availability, and changes made to placements during the 2009-2010 and 2010-2011 academic years and calculated capacity ratios for the advanced and introductory experience programs in the region. Comparisons also were made to previously published capacity results to determine whether the capacity ratio was useful in identifying trends and guiding preceptor and site development. Results. Capacity ratio calculations were successful in facilitating comparison of capacity within and across regions. Experiential education is solvent in the Northwest overall, but specific parts of experiential programs were found to have more capacity than others. Trends in the Northwest were consistent with capacity in other regions. Conclusions. The capacity ratio can determine and facilitate comparison of solvency within and across colleges and schools of pharmacy and thereby inform decisions about resource management in experiential education. This is the publisher’s final pdf. The published article is copyrighted by the American Association of Colleges of Pharmacy (AACP) and can be found at: http://www.ajpe.org/.

2011-12-15T00:00:00Z Boles, Myde Dilley, Julia A. Dent, Clyde Elman, Miriam R. Duncan, Susan C. Johnson, Donna B. http://hdl.handle.net/1957/38108 2013-04-10T22:01:20Z 2011-11-01T00:00:00Z

Changes in Local School Policies and Practices in Washington State After an Unfunded Physical Activity and Nutrition Mandate Boles, Myde; Dilley, Julia A.; Dent, Clyde; Elman, Miriam R.; Duncan, Susan C.; Johnson, Donna B. Introduction: Policies and practices in schools may create environments that encourage and reinforce healthy behaviors and are thus a means for stemming the rising rates of childhood obesity. We assessed the effect of a 2005 statewide school physical activity and nutrition mandate on policies and practices in middle and high schools in Washington State. Methods: We used 2002, 2004, and 2006 statewide School Health Profiles survey data from Washington, with Oregon as a comparison group, to create longitudinal linear regression models to describe changes in relevant school policies after the Washington statewide mandate. Policy area composite measures were generated by principal component factor analysis from survey questions about multiple binary measure policy and practice. Results: Relative to expected trends without the mandate, we found significant percentage-point increases in various policies, including restricted access to competitive foods in middle and high schools (increased by 18.8-20.0 percentage points); school food practices (increased by 10.4 percentage points in middle schools); and eliminating exemptions from physical education (PE) for sports (16.6 percentage-point increase for middle schools), exemptions from PE for community activities (12.8 and 14.4 percentage-point increases for middle and high schools, respectively) and exemptions from PE for academics (18.1 percentage-point increase for middle schools). Conclusion: Our results suggest that a statewide mandate had a modest effect on increasing physical activity and nutrition policies and practices in schools. Government policy is potentially an effective tool for addressing the childhood obesity epidemic through improvements in school physical activity and nutrition environments. This is the publisher’s final pdf. The published article is copyrighted by the Centers for Disease Control and Prevention, United States Government and can be found at: http://www.cdc.gov/pcd/current_issue.htm.

2011-11-01T00:00:00Z