Abstract:
The metabolic clearance rate (MCR) of plasma radioactivity after a
single intracardial injection of ³H-cortisol was elevated during the
Spring in yearling coho salmon, Oncorhynchus kisutch. The reasons for
this increase in MCR are not clear, but graphical analysis suggested
that there may be a seasonal correlation between MCR and gill
Na/K-ATPase activity. The main plasma metabolite of ³H-cortisol was
³H-cortisone, and it appeared very rapidly following injection of the
original radiotracer. The stress of handling as used in the injection
protocol and various anesthetic treatments did not affect clearance of
cortisol from plasma.
