The use of ethionamide has been increasing in drug regiments due to greater incidence of multidrug resistance tuberculosis around the world. Ethionamide is metabolized into antimicrobial relevant compounds by different f ...

Indole-3-carbinol (I3C) is a naturally occurring plant alkaloid, found in significant concentrations in cruciferous vegetables such as broccoli and Brussels sprouts. I3C is an unstable compound that undergoes rapid oli ...

Flavin-containing monooxygenase (FMO, EC1.14.13.8) comprises a family of xenobiotic-metabolizing enzymes that catalyze the oxygenation of a wide variety of xenobiotics, most commonly nitrogen and sulfur. Mammals expres ...

Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l ...

There is plenty of evidence from epidemiology studies supporting a link between certain components in the human diet and cancer incidence. It is estimated that 3-4 million annual cases of cancer could be prevented wor ...

Reported here is an investigation to determine the in vitro and in vivo metabolism of xanthohumol (XN). XN is the major prenylated flavonoid of the female inflorescences (cones) of the hop plant (Humulus lupulus). It i ...