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Browsing Department of Biochemistry and Biophysics by Author

Browsing Department of Biochemistry and Biophysics by Author "Gombart, Adrian F."

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C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice

Kyme, Pierre; Thoennissen, Nils H.; Tseng, Ching Wen; Thoennissen, Gabriela B.; Wolf, Andrea J.; Shimada, Kenichi; Krug, Utz O.; Lee, Kunik; Muller-Tidow, Carsten; Berdel, Wolfgang E.; Hardy, W. David; Gombart, Adrian F.; Koeffler, H. Phillip; Liu, George Y. (American Society for Clinical Investigation, 2012-09)

The myeloid-specific transcription factor, CCAAT/enhancer-binding protein epsilon (C/EBPε) is a critical mediator of myelopoiesis. Mutation of this gene is responsible for neutrophil-specific granule deficiency in humans ...
Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway

Guo, Chunxiao; Rosoha, Elena; Lowry, Malcolm B.; Borregaard, Niels; Gombart, Adrian F. (Elsevier, 2012)

The vitamin D receptor (VDR) mediates the pleiotropic biologic effects of 1alpha,25 dihydroxy-vitamin D3. Recent in vitro studies suggested that curcumin and poly-unsaturated fatty acids (PUFAs) also bind to VDR with l ...
Interplay between HIV-1 infection and host microRNAs

Sun, Guihua; Li, Haitang; Wu, Xiwei; Covarrubias, Maricela; Scherer, Lisa; Meinking, Keith; Luk, Brian; Chomchan, Pritsana; Alluin, Jessica; Gombart, Adrian F.; Rossi, John J. (Oxford University Press, 2012-03)

Using microRNA array analyses of in vitro HIV-1-infected CD4(+) cells, we find that several host microRNAs are significantly up- or downregulated around the time HIV-1 infection peaks in vitro. While microRNA-223 levels ...
Regulation of antimicrobial peptide gene expression by nutrients and byproducts of microbial metabolism

Campbell, Yan; Fantacone, Mary L.; Gombart, Adrian F. (Springer, 2012-12)

Background: Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense and deficiencies lead to ...