Browsing Department of Biochemistry and Biophysics by Subject "Histones"

Now showing items 1-4 of 4

Effects of nucleosomes on transcription by polymerase I in a reconstituted system

Georgel, Philippe, 1961- (1993-01-14)

The aim of this study was to gain more information about the interactions between DNA and the histone octamer during the process of transcription. This work used a pUC8 plasmid derivative that contained the core promo ...
The mechanism of interaction of the linker histone with DNA and nucleosomes

Ellen, Thomas Patrick (2003-06-27)

This dissertation examines the interaction of the linker histone with DNA and with nucleosomes. The first goal of the project was to characterize the interaction of the linker histone with DNA. Three factors previously ...
On the location of the linker histones and the linker DNA in the 30 nm fiber of chromatin

Leuba, Sanford H. (1993-05-07)

Understanding the structure of the 30 nm fiber in chromatin is relevant to understanding eukaryotic replication and transcription. The major controversy among the models of the fiber concerns the disposition of the linke ...
Towards the understanding of the function of the histone "tails" with respect to the structure, stability, and function of chromatin

Dong, Feng (1990-07-13)

By using immobilized trypsin, I have been able to prepare well-defined, stable trypsinized nucleosomes. The difficulties of lacking of control in the extent of trypsinization, which were encountered in previous studie ...