mirage

Faculty Research Publications (Biochemistry and Biophysics)

DSpace/Manakin Repository

Faculty Research Publications (Biochemistry and Biophysics)

 

Recent Submissions

  • Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C‐MYC depletion 
    Mannava, Sudha; Moparthy, Kalyana C.; Wheeler, Linda J.; Leonova, Katerina I.; Wawrzyniak, Joseph A.; Bianchi-Smiraglia, Anna; Berman, Albert E.; Flanagan, Sheryl; Shewach, Donna S.; Zeitouni, Nathalie C.; Gudkov, Andrei V.; Mathews, Christopher K.; Nikiforov, Mikhail A. (Impact Journals LLC., 2012-12)
    The down‐regulation of dominant oncogenes, including C‐MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC‐depl ...
  • Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression 
    Saldivar, Joshua C.; Miuma, Satoshi; Bene, Jessica; Hosseini, Seyed Ali; Shibata, Hidetaka; Sun, Jin; Wheeler, Linda J.; Mathews, Christopher K.; Huebner, Kay (Public Library of Science, 2012-11-29)
    Genomic instability drives tumorigenesis, but how it is initiated in sporadic neoplasias is unknown. In early preneoplasias, alterations at chromosome fragile sites arise due to DNA replication stress. A frequent, perhap ...
  • Regulation of antimicrobial peptide gene expression by nutrients and byproducts of microbial metabolism 
    Campbell, Yan; Fantacone, Mary L.; Gombart, Adrian F. (Springer, 2012-12)
    Background: Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense and deficiencies lead to ...
  • Functional Analyses of Trichoderma reesei LAE1 Reveal Conserved and Contrasting Roles of This Regulator 
    Karimi-Aghcheh, Razieh; Bok, Jin Woo; Phatale, Pallavi A.; Smith, Kristina M.; Baker, Scott E.; Lichius, Alexander; Omann, Markus; Zeilinger, Susanne; Seiboth, Bernhard; Rhee, Catherine; Keller, Nancy P.; Freitag, Michael; Kubicek, Christian P. (The Genetics Society of America, 2013-02-01)
    The putative methyltransferase LaeA is a global regulator that affects the expression of multiple secondary metabolite gene clusters in several fungi, and it can modify heterochromatin structure in Aspergillus nidulans. ...
  • Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice 
    Fok, Wilson C.; Zhang, Yiqiang; Salmon, Adam B.; Bhattacharya, Arunabh; Gunda, Rakesh; Jones, Dean; Ward, Walter; Fisher, Kathleen; Richardson, Arlan; Perez, Viviana I. (Oxford University Press, 2013-02)
    Because rapamycin, an inhibitor of the nutrient sensor mammalian target of rapamycin, and dietary restriction both increase life span of mice, it has been hypothesized that they act through similar mechanisms. To test th ...