Browsing Department of Environmental & Molecular Toxicology by Author "Lohr, Christiane"

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Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Shorey, Lyndsey; Castro, David J.; Baird, William; Siddens, Beth; Lohr, Christiane; Matzke, Melissa; Waters, Katrina M.; Corley, Richard A.; Williams, David E. (Elsevier, 2011-11-07)

Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 an ...