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Browsing Faculty Research Publications (Environmental & Molecular Toxicology) by Title

Browsing Faculty Research Publications (Environmental & Molecular Toxicology) by Title

Now showing items 6-19 of 19

Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells

Lee, Seong-Ho; Richardson, Raphael L.; Dashwood, Roderick H.; Baek, Seung Joan (Elsevier, 2012-06)

Capsaicin is a pungent ingredient in chili red peppers and has been linked to suppression of growth in various cancer cells. However, the underlying mechanism(s) by which capsaicin induces growth arrest and apoptosis of ...
Chemical and molecular characterization of fifteen species from the Lantana (Verbenaceae) genus

de Sena Filho, Jose Guedes; Carregosa Rabbani, Allivia Rouse; dos Santos Silva, Tania Regina; Cruz da Silva, Ana Veruska; Souza, Igor Azevedo; Bryanne Araujo Santos, Maria Jose; de Jesus, Jemmyson Romario; de Lima Nogueira, Paulo Cesar; Duringer, Jennifer M. (Elsevier, 2012-12)

The essential oil from two Lantana species (Lantana lucida Schauer and Lantana salzmannii Schauer) were evaluated for their chemical composition by GC-MS. Results showed 17 predominant compounds for L. lucida, among whic ...
Designing endocrine disruption out of the next generation of chemicals

Schug, T. T.; Abagyan, R.; Blumberg, B.; Collins, T. J.; Crews, D.; DeFur, P. L.; Dickerson, S. M.; Edwards, T. M.; Gore, A. C.; Guillette, L. J.; Hayes, T.; Heindel, J. J.; Moores, A.; Patisaul, H. B.; Tal, T. L.; Thayer, K. A.; Vandenberg, L. N.; Warner, J. C.; Watson, C. S.; vom Saal, F. S.; Zoeller, R. T.; O'Brien, K. P.; Myers, J. P. (The Royal Society of Chemistry, 2013)

A central goal of green chemistry is to avoid hazard in the design of new chemicals. This objective is best achieved when information about a chemical's potential hazardous effects is obtained as early in the design proc ...
Drug Repurposing in Chemical Genomics: Can We Learn from the Past to Improve the Future?

Bisson, William H. (Bentham Science Publishers, 2012-09)

More needs to be done by the private sector to optimize the drug discovery and development pipeline. In addition, significant efforts should also be focused on the understanding of mechanism of diseases, on the character ...
Effect of Native American Fish Smoking Methods on Dietary Exposure to Polycyclic Aromatic Hydrocarbons and Possible Risks to Human Health

Forsberg, Norman D.; Stone, Dave; Harding, Anna; Harper, Barbara; Harris, Stuart; Matzke, Melissa M.; Cardenas, Andres; Waters, Katrina M.; Anderson, Kim A. (American Chemical Society, 2012-07-11)

Although it is known that polycyclic aromatic hydrocarbons (PAHs) can be found in smoked meats, little is known about their prevalence in Native American smoked fish. In this work, the effect of traditional Native Americ ...
Interpreting Methamphetamine Levels in a High-Use Community

Chiaia-Hernandez, Aurea C.; Banta-Green, Caleb J.; Field, Jennifer A. (Springer, 2011-11-01)

Illicit drug use is a largely hidden phenomenon and population measures are notoriously problematic. Reliable and valid data for local, regional and national public health and other interventions are needed. To address t ...
ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format

Thomas, Dennis G.; Gaheen, Sharon; Harper, Stacey L.; Fritts, Martin; Klaessig, Fred; Hahn-Dantona, Elizabeth; Paik, David; Pan, Sue; Stafford, Grace A.; Freund, Elaine T.; Klemm, Juli D.; Baker, Nathan A. (BioMed Central Ltd., 2013-01-14)

Background and motivation: The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicin ...
MicroRNAs control neurobehavioral development and function in zebrafish

Tal, Tamara L.; Franzosa, Jill A.; Tilton, Susan C.; Philbrick, Kenneth A.; Iwaniec, Urszula T.; Turner, Russell T.; Waters, Katrina M.; Tanguay, Robert L. (Federation of American Societies for Experimental Biology, 2012-04)

microRNAs (miRNAs) have emerged as regulators of a broad spectrum of neurodevelopmental processes, including brain morphogenesis, neuronal differentiation, and survival. While the role of miRNAs in establishing and maint ...
Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse

Siddens, Lisbeth K.; Larkin, Andrew; Krueger, Sharon K.; Bradfield, Christopher A.; Waters, Katrina M.; Tilton, Susan C.; Pereira, Cliff B.; Lohr, Christiane V.; Arlt, Volker M.; Phillips, David H.; Williams, David E.; Baird, William M. (Elsevier, 2012-11-01)

The polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene (BaP), was compared to dibenzo[def,p]chrysene (DBC) and combinations of three environmental PAH mixtures (coal tar, diesel particulate and cigarette smoke condens ...
Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents

Crowell, Susan Ritger; Amin, Shantu G.; Anderson, Kim A.; Krishnegowda, Gowdahalli; Sharma, Arun K.; Soelberg, Jolen J.; Williams, David E.; Corley, Richard A. (Elsevier Inc., 2011-09-29)

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants generated as byproducts of natural and anthropogenic combustion processes. Despite significant public health concern, physiologically base ...
TCDD: An Environmental Immunotoxicant Reveals a Novel Pathway of Immunoregulation—A 30-Year Odyssey

Kerkvliet, Nancy I. (Sage Publications Inc., 2012-02)

I was honored to be the keynote speaker at the 30th Annual Society of Toxicologic Pathology Symposium “Toxicologic Pathology and the Immune System.” I had the opportunity to reminisce about events in the 1970s that set t ...
Temporal and spatial variation of atmospherically deposited organic contaminants at high elevation in Yosemite National Park, California, USA

Bradford, David F.; Stanley, Kerri A.; Tallent, Nita G.; Sparling, Donald W.; Nash, Maliha S.; Knapp, Roland A.; McConnell, Laura L.; Simonich, Staci L. Massey (John Wiley & Sons, Inc., 2013-03)

Contaminants used at low elevation, such as pesticides on crops, can be transported tens of kilometers and deposited in adjacent mountains in many parts of the world. Atmospherically deposited organic contaminants in the ...
Trace analysis of environmental matrices by large-volume injection and liquid chromatography-mass spectrometry

Busetti, Francesco; Backe, Will J.; Bendixen, Nina; Maier, Urs; Place, Benjamin; Giger, Walter; Field, Jennifer A. (Springer, 2012-01)

The time-honored convention of concentrating aqueous samples by solid-phase extraction (SPE) is being challenged by the increasingly wide spread use of large-volume injection (LVI) liquid chromatography-mass spectrometry ...
Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Shorey, Lyndsey; Castro, David J.; Baird, William; Siddens, Beth; Lohr, Christiane; Matzke, Melissa; Waters, Katrina M.; Corley, Richard A.; Williams, David E. (Elsevier, 2011-11-07)

Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 an ...