Abstract:
Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [¹⁴C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [¹⁴C] 3 weeks post dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens.
Description:
This is the author's peer reviewed final manuscript as accepted by the publisher. The published article is copyrighted by Elsevier and can be found here: http://www.elsevier.com/wps/find/journaldescription.cws_home/506050/description#description
NEWS COVERAGE: A news release based on this journal publication, which is written for a lay audience and has been approved by an author of the study, is available online: http://bit.ly/utdgfZ.
