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Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

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dc.creator Shorey, Lyndsey
dc.creator Castro, David J.
dc.creator Baird, William
dc.creator Siddens, Beth
dc.creator Lohr, Christiane
dc.creator Matzke, Melissa
dc.creator Waters, Katrina M.
dc.creator Corley, Richard A.
dc.creator Williams, David E.
dc.date.accessioned 2011-11-17T23:27:25Z
dc.date.available 2011-11-17T23:27:25Z
dc.date.issued 2011-11-07
dc.identifier.citation L. Shorey, D.J. Castro, W. Baird, B. Siddens, C. Löhr, M. Matzke, K.M. Waters, R.A. Corley, D.E. Williams, Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring, Cancer Letters (2011), doi: 10.1016/j.canlet. 2011.11.010 en_US
dc.identifier.uri http://hdl.handle.net/1957/25641
dc.description This is the author's peer reviewed final manuscript as accepted by the publisher. The published article is copyrighted by Elsevier and can be found here: http://www.elsevier.com/wps/find/journaldescription.cws_home/506050/description#description en_US
dc.description NEWS COVERAGE: A news release based on this journal publication, which is written for a lay audience and has been approved by an author of the study, is available online: http://bit.ly/utdgfZ.
dc.description.abstract Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [¹⁴C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [¹⁴C] 3 weeks post dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens. en_US
dc.description.sponsorship Support from this study was provided by the following PHS grants from NIH, P42 ES016465, P01 CA90890, T32ES07060 and P30 ES03850 along with assistance from The Linus Pauling Institute at Oregon State University. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Cancer Letters en_US
dc.relation.ispartofseries (2011) en_US
dc.subject transplancental cancer en_US
dc.subject PAHs en_US
dc.subject T-cell lymphoma en_US
dc.title Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring en_US
dc.type Article en_US
dc.description.peerreview yes en_US
dc.identifier.doi 10.1016/j.canlet.2011.11.010


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