Abstract:
F1FO-ATP synthase targeting antimicrobials apoptolidin 1 (A1), (+)-erythromefloquine,
and oligomycin were tested in vitro for synergistic minimum inhibitory
concentrations against Staphylococcus aureus. Synergy was strictly defined as inhibition
by at most 25% the MIC of each participating drug. Ampicillin, with an MIC of 0.8
ug/mL, served as a negative control. (+)-erythro-Mefloquine displayed an MIC of 12.5
ug/mL, while oligomycin had an MIC of 1.25 mg/mL. Apoptolidin A1 consistently
hindered, yet never completely inhibited, the growth of S. aureus. In combination, (+)-
erythro-mefloquine and apoptolidin A1 yielded an indifferent result. Oligomycin with
(+)-erythro-mefloquine displayed an antagonistic relationship. One trial of (+)-erythromefloquine
with ampicillin suggested an additive relationship might be present.
