Graduate Thesis Or Dissertation
 

Urinary excretion of 4-pyridoxic acid by women using steroid contraceptives and by mental retardates with and without Down's syndrome

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  • The urinary excretion of 4-pyridoxic acid (PIC), the principle end-product of vitamin B₆ metabolism found in human urine, was measured in two populations in whom altered vitamin B₆ metabolism has been reported: in women who use oral contraceptives and in mental retardates with and without Down's syndrome. In the first study 4 women who had been taking an oral contraceptive for 2 to 12 months served as experimental subjects; two women who did not use an oral contraceptive pill served as control subjects. They were placed on a constant diet that met the requirements for all essential nutrients. The study lasted for 11 days. During this period five 24-hr urine specimens were collected from each subject and were analyzed for 4-pyridoxic acid as well as for total creatinine. The urinary excretion of PIC by the subjects using an oral contraceptive was similar to that by the control group in this study and that by normal women subjects reported in the literature. The results of this study suggest that the alteration in vitamin B₆ metabolism observed in women using steroid contraceptives is not reflected by any change in urinary excretion of PIC. In general all subjects excreted more PIC during the latter part of the study than the initial stage, probably reflecting an adjustment to the higher intake of the vitamin supplied by the diet. Also, there was an inverse relationship between the urinary excretion of PIC and the body weight of the participants. In another study the excretion of PIC before and after pyridoxine (PIN) loading was studied in 12 patients with Down's syndrome and 12 mentally retarded controls without Down's syndrome. Three mongoloids and three non-mongoloids of the same sex and matched for age and weight were studied at a time for 6 days. They received a constant diet that was adequate in all essential nutrients for man. PIC was determined in urines collected on days 1, 5, and 6, 50 mg of pyridoxine being orally administered on day 5. Data show that the basal urinary excretion of PIC is similar in the mongoloid and control subjects. The total increase in PIC excretion by patients with Down's syndrome during the two days following the ingestion of the test dose of pyridoxine averaged 22.03 mg, while the excretion by the controls averaged 19.34 mg. The larger excretion of PIC by Down's syndrome patients compared with controls following pyridoxine loading was significant (P < 0.05). An explanation for this greater excretion by mongoloids is proposed.
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