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Effect of ethanol and low dietary copper on perinatal and postweanling copper utilization in the rat

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dc.contributor.advisor Cerklewski, Florian L.
dc.creator Baek, Jong Ho
dc.date.accessioned 2012-03-07T20:44:14Z
dc.date.available 2012-03-07T20:44:14Z
dc.date.copyright 1988-11-01
dc.date.issued 1988-11-01
dc.identifier.uri http://hdl.handle.net/1957/28160
dc.description Graduation date: 1989 en_US
dc.description.abstract The hypotheses of this research were (1) to test if the antagonistic effect of ethanol on liver copper could be seen within a short period when ethanol ingestion, low dietary copper and high metabolic demand represented by either pregnancy plus lactation or rapid growth are simultaneously present and (2) to test if ethanol ingestion would exaggerate a marginal dietary copper status to an obvious copper deficiency. Pregnant rats were fed liquid diets containing either 0.75 (low) or 3.75 (control) mg copper/L with or without 30% of kcal from ethanol throughout gestation and the first 15 days of lactation. Maternal ethanol intake failed to exaggerate a marginal copper status to a copper deficient anemia in both dams and pups as estimated by concentrations of hemoglobin and liver iron and oxidase activity of the copper-metalloenzyme ceruloplasmin. However, maternal ethanol intake did depress maternal liver copper concentration when diet copper was low (interactive effect P<0.05). This effect was specific for liver because other tissue copper concentration was unaffected by ethanol. Although ethanol depressed total pup liver copper concentration regardless of dietary copper level, the interactive effect seen in maternal liver was reflected in copper content of the pup liver metallothionein fraction eluted from a Sephadex G-75 column. At least part of the depressive effect of ethanol on pup liver copper can be explained by elevated pup serum corticosterone (r=-0.61, P<0.001), a hormone known to enhance loss of neonatal liver copper by way of biliary excretion. On the other hand, the copper status of weanling female rats which were fed liquid diets containing either 0.5 (low) or 2.5 (control) mg copper/L for 5 weeks was unaffected by ethanol. Results demonstrate that the depressive effect of ethanol on liver copper can be seen within a period of weeks rather than months when ethanol ingestion, low dietary copper and pregnancy plus lactation are simultaneously present in contrast to non-pregnancy. This ethanol and copper interaction during reproduction, however, can not be detected if only either serum copper or oxidase activity of ceruloplasmin is used as an indicator of copper status. en_US
dc.language.iso en_US en_US
dc.subject.lcsh Copper -- Bioavailability en_US
dc.subject.lcsh Alcohol -- Physiological effect en_US
dc.title Effect of ethanol and low dietary copper on perinatal and postweanling copper utilization in the rat en_US
dc.type Thesis/Dissertation en_US
dc.degree.name Doctor of Philosophy (Ph. D.) in Foods and Nutrition en_US
dc.degree.level Doctoral en_US
dc.degree.discipline Health and Human Sciences en_US
dc.degree.grantor Oregon State University en_US
dc.contributor.committeemember Woodburn, Margy J.
dc.contributor.committeemember Schaup, Henry W.
dc.contributor.committeemember Thomas, David R.
dc.description.digitization File scanned at 300 ppi (Monochrome) using Scamax Scan+ V. on a Scanmax 412CD by InoTec in PDF format. LuraDocument PDF Compressor V. used for pdf compression and textual OCR. en_US
dc.description.peerreview no en_us

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