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Application of ultrasonic welding to the rapid prototyping of microfluidic systems for biotechnology

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dc.contributor.advisor Paul, Brian K.
dc.contributor.advisor Jensen, Dean H.
dc.creator Aramphongphun, Chuckaphun
dc.date.accessioned 2012-05-23T17:57:10Z
dc.date.available 2012-05-23T17:57:10Z
dc.date.copyright 2001-08-31
dc.date.issued 2001-08-31
dc.identifier.uri http://hdl.handle.net/1957/29328
dc.description Graduation date: 2002 en_US
dc.description.abstract This paper introduces an alternative technique for the development of microfluidic systems for biotechnology based on mechanical machining and ultrasonic welding. Advantages of this approach over existing prototyping approaches involving the rapid development of tooling include: (a) short cycle time, (b) design flexibility, and (c) low cost manufacturing. In addition, the process provides a migration path to high volume production. A limitation of this system is that it cannot practically produce microchannels smaller than about 250 μm (0.010 in). However, for many biological cell-based biosensors, this feature scale seems well suited based on cell viability results. Several issues are discussed relevant to this approach, including bond strength, seal leakage, and sterilization. en_US
dc.language.iso en_US en_US
dc.subject.lcsh Rapid prototyping en_US
dc.subject.lcsh Machining en_US
dc.subject.lcsh Ultrasonic welding en_US
dc.subject.lcsh Micromechanics en_US
dc.subject.lcsh Microfluidic devices -- Design and construction en_US
dc.subject.lcsh Biosensors -- Design and construction en_US
dc.title Application of ultrasonic welding to the rapid prototyping of microfluidic systems for biotechnology en_US
dc.type Thesis/Dissertation en_US
dc.degree.name Master of Science (M.S.) in Industrial Engineering en_US
dc.degree.level Master's en_US
dc.degree.discipline Engineering en_US
dc.degree.grantor Oregon State University en_US
dc.contributor.committeemember Kim, David
dc.contributor.committeemember Rathja, Roy
dc.description.digitization File scanned at 300 ppi (Monochrome, 8-bit Grayscale) using ScandAll PRO 1.8.1 on a Fi-6670 in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR. en_US
dc.description.peerreview no en_us

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