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Inhibition of α-Amylase and α-Glucosidase by Bioflavonoids

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dc.contributor.advisor Frei, Balz
dc.creator Griffith, Anneke M. (Tucker)
dc.date.accessioned 2012-06-19T16:17:59Z
dc.date.available 2012-06-19T16:17:59Z
dc.date.copyright 2012-03-05
dc.date.issued 2012-06-19
dc.identifier.uri http://hdl.handle.net/1957/29953
dc.description June 2012 en_US
dc.description.abstract Various flavonoid-rich plant extracts have shown efficacy in the treatment of diabetes. Although it is often assumed that dietary flavonoids exert biological antioxidant effects, it is possible that the observed effects work in carbohydrate metabolism. In this study we evaluated the effect of catechins and catechin containing extracts on α-amylase and α-glucosidase activity, enzymes of great importance in carbohydrate metabolism and diabetes mellitus. Grape seed extract, white tea and green tea were tested, as well as their constituent catechins, or flavon-3-ols: catechin, epicatechin, epigallocatechin, epigallocatechin gallate, gallocatechin gallate, and epicatechin gallate. In all tests, acarbose, a pharmacological inhibitor of α-glucosidases was included as a positive control. For each compound, the concentration required for 50% inhibition of enzyme activity was determined to compare the potency. For α-amylase, grape seed extract demonstrated a similar α-amylase inhibitory activity to acarbose and white and green tea extracts showed a weaker inhibition. In α-glucosidase experiments, grape seed, green and white tea extracts inhibited enzymatic activity much more strongly than acarbose. The inhibitory activities of individual catechins are also reported. With this information, it is possible that catechins and certain plant extracts play a role in the prevention or treatment of type II diabetes mellitus. en_US
dc.language.iso en_US en_US
dc.subject α-amylase en_US
dc.subject α-glucosidase en_US
dc.subject diabetes en_US
dc.subject bioflavonoids en_US
dc.subject catechins en_US
dc.title Inhibition of α-Amylase and α-Glucosidase by Bioflavonoids en_US
dc.type Research Paper en_US
dc.degree.level Bachelor's en_US
dc.degree.discipline Interdisciplinary Studies en_US
dc.degree.grantor Oregon State University en_US
dc.contributor.committeemember Yilmazer-Musa, Meltem
dc.contributor.committeemember Field, Katharine G.


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