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The changes they are a-timed: metabolism, endogenousclocks, and the timing of puberty

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dc.creator Tolson, Kristen P.
dc.creator Chappell, Patrick E.
dc.date.accessioned 2012-06-25T16:11:43Z
dc.date.available 2012-06-25T16:11:43Z
dc.date.issued 2012-03-28
dc.identifier.citation Tolson, K. P., & Chappell, P. E. (2012, March 28). The changes they are a-timed: metabolism, endogenousclocks, and the timing of puberty. Frontiers in Endocrinology, 3. doi:10.3389/fendo.2012.00045 en_US
dc.identifier.uri http://hdl.handle.net/1957/30120
dc.description This document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. en_US
dc.description.abstract Childhood obesity has increased dramatically over the last several decades, particularly in industrialized countries, often accompanied by acceleration of pubertal progression and associated reproductive abnormalities (Biro et al., 2006; Rosenfield et al., 2009). The timing of pubertal initiation and progression in mammals is likely influenced by nutritional and metabolic state, leading to the hypothesis that deviations from normal metabolic rate, such as those seen in obesity, may contribute to observed alterations in the rate of pubertal progression. While several recent reviews have addressed the effects of metabolic disorders on reproductive function in general, this review will explore previous and current models of pubertal timing, outlining a potential role of endogenous timing mechanisms such as cellular circadian clocks in the initiation of puberty, and how these clocks might be altered by metabolic factors. Additionally, we will examine recently elucidated neuroendocrine regulators of pubertal progression such as kisspeptin, explore models detailing how the mammalian reproductive axis is silenced during the juvenile period and reactivated at appropriate developmental times, and emphasize how metabolic dysfunction such as childhood obesity may alter timing cues that advance or delay pubertal progression, resulting in diminished reproductive capacity. en_US
dc.language.iso en_US en_US
dc.publisher Frontiers Research Foundation en_US
dc.relation.ispartofseries Frontiers in Endocrinology en_US
dc.relation.ispartofseries Vol. 3 en_US
dc.subject obesity en_US
dc.subject kisspeptin en_US
dc.subject circadian en_US
dc.subject puberty en_US
dc.subject GnRH en_US
dc.title The changes they are a-timed: metabolism, endogenousclocks, and the timing of puberty en_US
dc.type Article en_US
dc.identifier.doi 10.3389/fendo.2012.00045


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