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Browsing Faculty Research Publications (College of Pharmacy) by Title

Browsing Faculty Research Publications (College of Pharmacy) by Title

Now showing items 11-22 of 22

Loss of Abdominal Muscle in Pitx2 Mutants Associated with Altered Axial Specification of Lateral Plate Mesoderm

Eng, Diana; Ma, Hsiao-Yen; Xu, Jun; Shih, Hung-Ping; Gross, Michael K.; Kiouss, Chrissa (Public Library of Science, 2012-07-31)

Sequence specific transcription factors (SSTFs) combinatorially define cell types during development by forming recursively linked network kernels. Pitx2 expression begins during gastrulation, together with Hox genes, an ...
Mechanistic Insights into Validoxylamine A 7’-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

Cavalier, Michael C.; Yim, Young-Sun; Asamizu, Shumpei; Neau, David; Almabruk, Khaled H.; Mahmud, Taifo; Lee, Yong-Hwan (Public Library of Science, 2012-09-13)

The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form ...
Nanostructured Lipid Carriers as Multifunctional Nanomedicine Platform for Pulmonary Co-Delivery of Anticancer Drugs and siRNA

Oleh Taratula; Andriy Kuzmov; Milin Shah; Olga B. Garbuzenko; Tamara Minko (Elsevier, 2013-04-28)

We developed, synthesized, and tested a multifunctional nanostructured lipid nanocarrier- based system (NLCS) for efficient delivery of an anticancer drug and siRNA directly into the lungs by inhalation. The system conta ...
A pilot study evaluating alternative approaches of academic detailing in rural family practice clinics

Hartung, Daniel M.; Hamer, Ann; Middleton, Luke; Haxby, Dean; Fagnan, Lyle J. (BioMed Central Ltd., 2012-12-31)

Background: Academic detailing is an interactive, convenient, and user-friendly approach to delivering non-commercial education to healthcare clinicians. While evidence suggests academic detailing is associated with impr ...
Pitx2 expression induces cell cycle exit and p21 expression in neural stem cells

Heldring, Nina; Joseph, Bertrand; Hermanson, Ola; Kioussi, Chrissa (Bentham Science Publishers, 2012-11-01)

Cortical development is a complex process that involves many events including proliferation, cell cycle exit, and differentiation that need to be appropriately synchronized.. Neural stem cells (NSCs) isolated from embryo ...
Population-Specific Regulation of Chmp2b by Lbx1 during Onset of Synaptogenesis in Lateral Association Interneurons

Xu, Jun; Nonogaki, Mariko; Madhira, Ravi; Ma, Hsiao-Yen; Hermanson, Ola; Kioussi, Chrissa; Gross, Michael K. (Public Library of Science, 2012-12-21)

Chmp2b is closely related to Vps2, a key component of the yeast protein complex that creates the intralumenal vesicles of multivesicular bodies. Dominant negative mutations in Chmp2b cause autophagosome accumulation and ...
Pseudoprogression of Glioblastoma after Chemo- and Radiation Therapy: Diagnosis by Using Dynamic Susceptibilityweighted Contrast-enhanced Perfusion MR Imaging with Ferumoxytol versus Gadoteridol and Correlation with Survival

Gahramanov, Seymur; Muldoon, Leslie L.; Varallyay, Csanad G.; Li, Xin; Kraemer, Dale F.; Fu, Rongwei; Hamilton, Bronwyn E.; Rooney, William D.; Neuwelt, Edward A. (Radiological Society of North America, 2013-03)

Purpose: To compare gadoteridol and ferumoxytol for measurement of relative cerebral blood volume (rCBV) in patients with glioblastoma multiforme (GBM) who showed progressive disease at conventional magnetic resonance (M ...
Regulation of Motility of Myogenic Cells in Filling Limb Muscle Anlagen by Pitx2

Campbell, Adam L.; Shih, Hung-Ping; Xu, Jun; Gross, Michael K.; Kioussi, Chrissa (PLoS, 2012-04-27)

Cells of the ventrolateral dermomyotome delaminate and migrate into the limb buds where they give rise to all muscles of the limbs. The migratory cells proliferate and form myoblasts, which withdraw from the cell cycle t ...
Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

Wang, Zhixing; Zhang, Ling-juan; Guha, Gunjan; Li, Shan; Kyrylkova, Kateryna; Kioussi, Chrissa; Leid, Mark; Ganguli-Indra, Gitali; Indra, Arup K. (Public Library of Science, 2012-12-20)

Background: Ctip2 is crucial for epidermal homeostasis and protective barrier formation in developing mouse embryos. Selective ablation of Ctip2 in epidermis leads to increased transepidermal water loss (TEWL), impaired ...
Tacrolimus Pharmacokinetics in Hispanic Children After Kidney Transplantation

Cherala, G.; Munar, M. Y.; Naher, A.; Al-Uzri, A. (Elsevier, 2011-12)

Ethnic differences in drug pharmacokinetics are well recognized including that for tacrolimus (TAC) in adult subjects. However, similar knowledge among pediatric populations is missing. Our limited retrospective study co ...
Transcriptional Regulation and Increased Production of Asukamycin in Engineered Streptomyces nodosus subsp. asukaensis Strains

Xie, Pengfei; Sheng, Yan; Ito, Takuya; Mahmud, Taifo (Springer, 2012-10)

Asukamycin, a member of the manumycin family of antibiotics, exhibits strong antibacterial, antifungal, and anti-neoplastic activities. However, its production in the wild-type strain of Streptomyces nodosus subsp. asuka ...
Understanding Statin Use in America and Gaps in Patient Education (USAGE): An Internet-Based Survey of 10,138 Current and Former Statin Users

Cohen, Jerome D.; Brinton, Eliot A.; Ito, Matthew K.; Jacobson, Terry A. (Elsevier, 2012-05)

Background: Statins substantially reduce cardiovascular disease risk and are generally well-tolerated, but many patients discontinue therapy. A better understanding of the characteristics of current and former statin use ...