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Tacrolimus Pharmacokinetics in Hispanic Children After Kidney Transplantation

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dc.creator Cherala, G.
dc.creator Munar, M. Y.
dc.creator Naher, A.
dc.creator Al-Uzri, A.
dc.date.accessioned 2012-10-10T18:07:48Z
dc.date.available 2012-10-10T18:07:48Z
dc.date.issued 2011-12
dc.identifier.citation Cherala, G., Munar, M., Naher, A., & Al-Uzri, A. (2011). Tacrolimus pharmacokinetics in hispanic children after kidney transplantation. TRANSPLANTATION PROCEEDINGS, 43(10), 3708-3712. doi: 10.1016/j.transproceed.2011.09.016 en_US
dc.identifier.uri http://hdl.handle.net/1957/34316
dc.description This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier and can be found at: http://www.journals.elsevier.com/transplantation-proceedings/. en_US
dc.description.abstract Ethnic differences in drug pharmacokinetics are well recognized including that for tacrolimus (TAC) in adult subjects. However, similar knowledge among pediatric populations is missing. Our limited retrospective study compares steady-state pharmacokinetics of TAC in Hispanic versus non-Hispanic children. Serial blood samples were collected and whole blood concentrations of TAC were measured using radioimmunoassay. Compared with non-Hispanic children, Hispanic children had lower measures of drug exposure (maximum drug concentration [C(subscript max)] and area under the drug concentration-time curve [AUC(subscript 0-∞)]), higher volume of distribution, and faster clearance. Interestingly, only in Hispanic children, significant correlations were found between body weight and clearance, age and volume of distribution, and Schwartz estimated glomerular filtration rate and half-life. In conclusion, our study suggests that ethnic differences exist between Hispanic and non-Hispanic children in TAC PK, and based on our preliminary findings, either a higher or more frequent TAC dosing may be required for effective immunosuppression therapy in Hispanic children. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Transplantation Proceedings en_US
dc.relation.ispartofseries Vol. 43 no. 10 en_US
dc.title Tacrolimus Pharmacokinetics in Hispanic Children After Kidney Transplantation en_US
dc.type Article en_US
dc.description.peerreview yes en_US
dc.identifier.doi 10.1016/j.transproceed.2011.09.016

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