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Novel bioactive secondary metabolites from the marine cyanobacterium Lyngbya majuscula

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dc.contributor.advisor Gerwick, William H.
dc.creator Wu, Min, 1963-
dc.date.accessioned 2012-10-12T18:03:43Z
dc.date.available 2012-10-12T18:03:43Z
dc.date.copyright 1996-09-13
dc.date.issued 1996-09-13
dc.identifier.uri http://hdl.handle.net/1957/34363
dc.description Graduation date: 1997 en_US
dc.description.abstract Marine algae have been recognized as a rich resource of new and unusual organic molecules with diverse biological properties. The current need to develop new antifungal, anticancer, antibiotic and antiviral drugs has led to an intense research effort into the discovery, isolation and structure determination of potential medicinal agents from marine algae. In the past two years, I have participated in a drug discovery program designed for antitumor, antifungal and other agents of potential pharmaceutical utility from the marine cyanobacterium Lyngbya majuscula. This research utilized modern chromatographic and spectrochemical techniques including 2D NMR spectroscopy. Brine shrimp toxicity guided the fractionation that led to the discovery of the biologically active compound kalkitoxin from a Curacao Lyngbya majuscula extract. The structure of this new thiazoline ring-containing lipid was determined spectroscopically by interpretation of 2D-NMR experiments, including heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple-bond coherence spectroscopy (HMBC) and ¹H-¹H COSY at room temperature and elevated temperature. Kalkitoxin shows modest molluscicidal toxicity, good brine shrimp toxicity and extremely potent ichthyotoxicity. From the same extract of Lyngbya majuscula, I also isolated two other secondary metabolites, malyngamide J and malyngamide L. The structures of these new compounds, including stereochemistry, were determined by spectroscopic techniques including 2D-NMR experiments and by comparison with other known malyngamides. en_US
dc.language.iso en_US en_US
dc.subject.lcsh Lyngbya en_US
dc.subject.lcsh Marine pharmacology en_US
dc.subject.lcsh Marine metabolites en_US
dc.subject.lcsh Metabolism, Secondary en_US
dc.title Novel bioactive secondary metabolites from the marine cyanobacterium Lyngbya majuscula en_US
dc.type Thesis/Dissertation en_US
dc.degree.name Master of Science (M.S.) in Pharmacy en_US
dc.degree.level Master's en_US
dc.degree.discipline Pharmacy en_US
dc.degree.grantor Oregon State University en_US
dc.contributor.committeemember Gable, Kevin
dc.contributor.committeemember Constantine, George H.
dc.contributor.committeemember Bailey, George S.
dc.description.digitization File scanned at 300 ppi (Monochrome, 8-bit Grayscale) using ScandAll PRO 1.8.1 on a Fi-6670 in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR. en_US
dc.description.peerreview no en_us

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