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Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial

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dc.creator Bobe, Gerd
dc.creator Murphy, Gwen
dc.creator Albert, Paul S.
dc.creator Sansbury, Leah B.
dc.creator Lanza, Elaine
dc.creator Schatzkin, Arthur
dc.creator Cross, Amanda J.
dc.date.accessioned 2012-10-31T18:31:28Z
dc.date.available 2012-10-31T18:31:28Z
dc.date.issued 2012-04-01
dc.identifier.citation Bobe, G., Murphy, G., Albert, P. S., Sansbury, L. B., Lanza, E., Schatzkin, A., & Cross, A. J. (2012). Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the polyp prevention trial. International Journal of Cancer. Journal International Du Cancer, 130(7), 1649-1659. doi: 10.1002/ijc.26184 en_US
dc.identifier.uri http://hdl.handle.net/1957/34711
dc.description This is the publisher’s final pdf. The published article is copyrighted by Wiley and can be found at: http://onlinelibrary.wiley.com/. en_US
dc.description.abstract Lignans and proanthocyanidins are plant polyphenols that have shown protective properties against colorectal neoplasms in some human studies. Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to prospectively evaluate the association between lignan and proanthocyanidin intake, estimated from databases linked to a food frequency questionnaire, and adenoma recurrence in 1,859 participants of the Polyp Prevention Trial. Overall, individual or total lignans or proanthocyanidins were not associated with colorectal adenoma recurrence. However, in sex-specific analyses, total lignan intake was positively associated with any adenoma recurrence in women (highest vs. lowest lignan intake quartile OR = 2.07, 95% CI: 1.223.52, p trend = 0.004) but not in men (p interaction = 0.04). To conclude, dietary lignan and proanthocyanidin consumption were not generally related to colorectal adenoma recurrence; however, high lignan intake may increase the risk of adenoma recurrence in women. en_US
dc.description.sponsorship Intramural Research Program, National Cancer Institute, NIH, DHHS (Bethesda, MD) en_US
dc.language.iso en_US en_US
dc.publisher Wiley en_US
dc.relation.ispartofseries International Journal of Cancer en_US
dc.relation.ispartofseries Vol. 130 No. 7 en_US
dc.subject Cancer prevention en_US
dc.subject Colorectal adenoma en_US
dc.subject Colorectal cancer en_US
dc.subject Lignans en_US
dc.subject Proanthocyanidins en_US
dc.title Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial en_US
dc.type Article en_US
dc.description.peerreview yes en_US
dc.identifier.doi 10.1002/ijc.26184


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