Graduate Thesis Or Dissertation
 

Prevalance [sic] of senile dementia of the Alzheimer type (SDAT) in females receiving postmenopausal conjugated estrogen vs. controls : a retrospective review

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/dv13zz32j

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  • Recent in vitro data provide evidence that estrogen may assist in the maintenance of nervous tissue viability. Anecdotal reports suggest a lower prevalence of SDAT in postmenopausal women who have received estrogen replacement therapy although published data are conflicting. The purposes of this study are to determine whether the incidence of SDAT differs between males and postmenopausal females, and whether an inverse association exists between postmenopausal estrogen replacement therapy and SDAT. The data sets analyzed were the Oregon Public Employees Retirement System (PERS) (n=18,893) and pharmacy databases for 118 long term care facilities in Oregon (n=3141). Logit analysis odds ratio, adjusted for age, for conjugated estrogen exposure was 0.51 (95% confidence interval 0.26-0.97). Although daily dose and length of therapy also indicated a reduced odds ratio for estrogen users vs. non-users, the results are equivocal with this database. In conclusion, this database provides evidence that estrogen replacement therapy has a positive impact on the prevalence of SDAT in postmenopausal women, although the effect of length of treatment and total cumulative dose remain unclear.
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