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The effect of agility exercise on eicosanoid excretion, oxidant status, and plasma lactate in dogs

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  • urinary eicosanoids, urinary 15F[subscript2t]-isoprostane (lipid peroxidation marker) and hematological/biochemical changes in plasma. Fifteen adult dogs had blood and urine samples obtained prior to, immediately and 4-hours following an agility exercise. Results: Hematocrit, red blood cells (RBC), albumin, and hemoglobin increased following exercise, with greatest increases correlating to increased skill group (novice, intermediate, masters); at 4-hours post-exercise, hematocrit, RBC, and hemoglobin were decreased. Phosphorus increased following exercise with the greatest increase in novice and intermediates. Plasma lactate increased 3.6-fold in masters, 3.2-fold in intermediates, and 1.2-fold in novice dogs. Urine thromboxane B-2 (TXB2) more than tripled 4-hours post-exercise while 6-keto prostaglandin F[subscript 1 alpha] (PGF1 alpha, prostacyclin metabolite), prostaglandin E[subscript 2] metabolites (13,14-dihydro-15-keto-prostaglandin A[subscript 2] and 13, 14-dihydro-15-keto-prostaglandin E[subscript 2], and 13,14-dihydro-15-keto prostaglandin F[subscript 2 alpha] were unaffected as determined by a competitive enzyme immunoassay and standardized by division with urine creatinine. Urine 15F[subscript 2t]-isoprostane increased insignificantly. Conclusions: Alterations in the plasma post-exercise were likely due to hemoconcentration from insensible water loss, splenic contraction and sympathetic stimulation while 4-hours later autohemodilution reduced RBC parameters. Elevations in plasma lactate and urinary TXB2 correlated with advanced skill level/speed of the dogs.
  • Keywords: Oxidant stress, Agility exercise, Urinary eicosanoids, Thromboxane B[subscript 2], Dog, Plasma lactate, Urinary isoprostane
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  • Baltzer, W. I., Firshman, A. M., Stang, B., Warnock, J. J., Gorman, E., & McKenzie, E. C. (2012). The effect of agility exercise on eicosanoid excretion, oxidant status, and plasma lactate in dogs. BMC Veterinary Research, 8(1), 249-249. doi: 10.1186/1746-6148-8-249
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  • 8
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