Graduate Thesis Or Dissertation

 

Dissolution and bioavailability of immediate and sustained release cold and cough dosage forms Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/08612r63g

Descriptions

Attribute NameValues
Creator
Abstract
  • A high-pressure liquid chromatography method based on reported literature was developed for the quantitative analysis of chlorpheniramine, pseudoephedrine, phenylpropanolamine and acetaminophen in dissolution fluids and urine. The effects of buffer, pH and different concentrations of organic solvent in the mobile phase on chromatographic separation are described in Chapter I. Dissolution studies using the USP rotating-basket method were carried out on several commercially available brands of sustained and immediate release products. Dissolution pattern comparisons among products provided preliminary data before conducting a relative bioavailability study. Relative bioavailability of chlorpheniramine from one immediate and two sustained-release products was determined in a urinary excretion study using 4 normal healthy subjects. Urinary excretion of acetaminophen was also studied in these four subjects. Bioavailability results were consistent with dissolution results.
Resource Type
Date Available
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Publisher
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi (Monochrome) using ScandAll PRO 1.8.1 on a Fi-6670 in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR.
Replaces

Relationships

Parents:

This work has no parents.

In Collection:

Items