Determination of ionization constants by chromatography

Graduate Thesis Or Dissertation

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Citeable URL: https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/c821gn10v

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Attribute Name	Values
Creator	Palalikit, Darawan
Abstract	The determination of the pKa's of several organic acids and bases using chromatography was investigated. Normal-phase buffer-impregnated paper chromatography was found to be unsuitable. TLC plates impregnated with mineral oil were examined as a possible reversed-phase method, with poor results. The use of XAD-2 copolymer as the stationary phase in a simple HPLC method gave good results. Experimentally determined pKa values were confirmed using UV spectrophotometry with the identical solvents and buffers used in the HPLC method. Statistical comparisons using both pKa and Ka values were performed. The advantage of using a computer method involving the second derivative to determine pKa was illustrated.
Resource Type	Masters Thesis
Date Available	2013-09-16T21:17:07+00:00
Date Issued	1979-03-09
Degree Level	Master's
Degree Name	Master of Science (M.S.)
Degree Field	Pharmacy
Degree Grantor	Oregon State University
Commencement Year	1979
Advisor	Block, John H.
Academic Affiliation	School of Pharmacy
Non-Academic Affiliation	Oregon State University. Graduate School
Subject	Ionization
Rights Statement	Copyright Not Evaluated
Publisher	Oregon State University
Peer Reviewed	No
Language	English [eng]
Digitization Specifications	File scanned at 300 ppi (Monochrome) using ScandAll PRO 1.8.1 on a Fi-6670 in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR.
Replaces	http://hdl.handle.net/1957/42537

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