Graduate Thesis Or Dissertation
 

The effect of 2, 4-dichlorophenoxyacetic acid on the vivo metabolism of acetate in rats

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  • Normal adult rats absorbed and metabolized C¹⁴-labeled acetate rapidly. The greatest percentage of the administered radioactivity was recovered in the expired CO₂, however small amounts of radioactivity were also found in the urine and feces. There were two rates of C¹⁴O₂ elimination in normal adult rats. The small amount of radioactivity recovered in the urine was found to consist of several different metabolites; their relative abundance was dependent upon the sex of the rat and the C¹⁴-labeled acetate used. Orally administered 2,4-D was found to effect the secondary rate of C¹⁴O₂ elimination, and to reduce the percentage of radioactivity recovered. The presence of 2,4-D altered the pattern of radioactive metabolites found in the urine. In females, the effect of 2,4-D was greater on the metabolism of the methyl carbon than on the carboxyl carbon of acetate. The presence of 2,4-D was found to have a similar effect on the rate of C¹⁴O₂ elimination over a wide range of dosages. At lower dosages, five milligrams or less per rat, the effect was reduced. The accumulative recovery of radioactivity was increased as the dosage of 2,4-D was decreased. When the time between 2,4-D treatment and acetate administration was increased, up to 48 hours, a similar effect on the C¹⁴O₂ elimination rate was observed. However, there was a trend toward greater recovery of the radioactivity. With a pretreatment time of one week, 2,4-D showed no effect on the acetate metabolism. Large amounts of radioactivity were found in the stomach of rats given 2,4-D and acetate-1-C¹⁴ orally. From this it was concluded that 2,4-D was affecting the absorption of acetate. This conclusion was further verified when 2,4-D was given orally, and acetate was injected into the peritoneal cavity. In this work,2,4-D did not alter the C¹⁴O₂ elimination pattern, although there was a slight reduction in the percentage of the radioactivity recovered.
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